Protein Alignment Vang and VANGL1

DIOPT Version :10

• Sequence 1: NP_001260819.1
• Gene: Vang / 35922
• FlyBaseID: FBgn0015838
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_620409.1
• Gene: VANGL1 / 81839
• HGNCID: 15512
• Length: 524
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 257/587 - (43%)
• Similarity: 359/587 - (61%)
• Gaps: 69/587 - (11%)

  Fly     1 MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGF 65
            |:.||..|.:|..|..|:..                      ||:.:|:|..|:|.. :|..:|.
Human     1 MDTESTYSGYSYYSSHSKKS----------------------HRQGERTRERHKSPR-NKDGRGS 42

  Fly    66 QRGDMAPYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMEDINNMWHRE 130
            ::.......|...:.|:.|...:||       ||:||||.|||:|| |||.|||.|||..: .::
Human    43 EKSVTIQPPTGEPLLGNDSTRTEEV-------QDDNWGETTTAITG-TSEHSISQEDIARI-SKD 98

  Fly   131 SDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVRTQLLACSEQC 195
            .:......|:||:..:....||...|.:|:|.:::|.:.:              |.:|..|...|
Human    99 MEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILW--------------RDELEPCGTIC 149

  Fly   196 KGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIVQVTNGAKI 260
            :|..:|:|.:||:|.||.||:|.|:..|.|||:|::|||:|:|:.:...:|||||      |.:|
Human   150 EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFY------GVRI 208

  Fly   261 VVETGGDAVD--YKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVSRSYMLG 323
            :     |:.|  |:.:|.||.:.||.||||||:|:||||||..||.:.::::||.||.||.|.||
Human   209 L-----DSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLG 268

  Fly   324 QLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQQQSQSRAV 388
            .|||||||:.||::||.||.|:||.|    ::.||.:..|.....|.|.|||.||: ...||||:
Human   269 HLSIQRAALVVLENYYKDFTIYNPNL----LTASKFRAAKHMAGLKVYNVDGPSNN-ATGQSRAM 328

  Fly   389 LAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNE---PAPALPLDPQEA 450
            :||.||||||||||.:|||.|:|||||||:|||:.|.||||.||:|:..|   .||...:||:||
Human   329 IAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREA 393

  Fly   451 ASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESPVMQSEKERR 515
            |.|:|||||||||||||:||||..|:.||||:|||.|:.:.::|:||||.||:..|.:|.:|: |
Human   394 AQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKD-R 457

  Fly   516 WVQS-WSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKFVLKLNSET 579
            |:.: |.|:.||.|:..:.:...|.|...|.||:|.|.|:|...|:||.:||||:||||:|.|||
Human   458 WLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSET 522

  Fly   580 SV 581
            ||
Human   523 SV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	43..581	CDD:461971	248/543 (46%)
VANGL1	NP_620409.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..85		33/114 (29%)
		Strabismus	25..524	CDD:461971	246/539 (46%)