Protein Alignment Vang and Vangl2

DIOPT Version :10

• Sequence 1: NP_001260819.1
• Gene: Vang / 35922
• FlyBaseID: FBgn0015838
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001099439.1
• Gene: Vangl2 / 289229
• RGDID: 1309442
• Length: 521
• Species: Rattus norvegicus
• Alignment Length: 595
• Identity: 259/595 - (43%)
• Similarity: 353/595 - (59%)
• Gaps: 88/595 - (14%)

  Fly     1 MENESVKSEH---SGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSA 62
            |:.||..|.:   ||.||.||.|                         |||     |..|.|||.
  Rat     1 MDTESQYSGYSYKSGHSRSSRKH-------------------------RDR-----RDRHRSKSR 35

  Fly    63 KGFQRGDMAPYQTSVNMTGDG-------SHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISM 120
            .| .|||     .||.:...|       |..|.|        :|:||||.||.||| |||.|||.
  Rat    36 DG-SRGD-----KSVTIQAPGEPLLDNESTRGDE--------RDDNWGETTTVVTG-TSEHSISH 85

  Fly   121 EDINNMWHRESDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVR 185
            :|:..: .::.:......|.|::..:...:|...:|.:|:|.:::|     |..:         |
  Rat    86 DDLTRI-AKDMEDSVPLDCSRHLGVAAGAILALLSFLTPLAFLLLP-----PLLW---------R 135

  Fly   186 TQLLACSEQCKGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFY 250
            .:|..|...|:|..:|:|.:||:|.:|.||:|.||..|::||:|:.|||:::||.:...:|||||
  Rat   136 EELEPCGTACEGLFISVAFKLLILLLGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFY 200

  Fly   251 IVQVTNGAKIVVETGGDAVDYKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDG 315
            .|::.:..:         ..|:.:|.:|.:.||.|||:||:||||||||..||.:.:|::||.||
  Rat   201 GVRILDARE---------RSYQGVVQFAVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDG 256

  Fly   316 VSRSYMLGQLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQ 380
            .||.|.:|.|||||.|||:|:.||.|||::||.|..:|.||   ...|:| .||.|.: |..||.
  Rat   257 ASRFYNVGHLSIQRVAVWILEKYYHDFPVYNPALLNLPKSV---LAKKVS-GFKVYSL-GEENST 316

  Fly   381 QQS--QSRAVLAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNEPA--P 441
            ..|  |||||:||.|||||:||||.:|||.|:||||:||||||:.|.|||||||||:..|..  |
  Rat   317 NNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNP 381

  Fly   442 ALPLDPQEAASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESP 506
            ...:||:|||.|:|.|||||:|||||.|:|||.||.||||:||..|:.||::|:||||.||...|
  Rat   382 REVMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGP 446

  Fly   507 VMQSEKERRWVQSWSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKF 571
            .:|..|||...:.|:|:.:|.|:..:.:...|.|.:.|.||:|:..|:|.|.|:||.|||||:||
  Rat   447 TIQYHKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKSHKF 511

  Fly   572 VLKLNSETSV 581
            |::|.|||||
  Rat   512 VMRLQSETSV 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vang	NP_001260819.1	Strabismus	43..581	CDD:461971	246/548 (45%)
Vangl2	NP_001099439.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		41/124 (33%)
		Strabismus	34..521	CDD:461971	239/530 (45%)