Protein Alignment babo and acvrl1

DIOPT Version :10

• Sequence 1: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_021325397.1
• Gene: acvrl1 / 266753
• ZFINID: ZDB-GENE-021003-1
• Length: 507
• Species: Danio rerio
• Alignment Length: 522
• Identity: 233/522 - (44%)
• Similarity: 307/522 - (58%)
• Gaps: 74/522 - (14%)

  Fly   121 KKPENKIKCHCDTCKESNNICETDGFCFTSVEKNSDGSIIFSYRCLHK----------SQIFPPG 175
            |..|:.::|.|    |:.|:||.:. |:        |.|.| |..:|:          .|.:.|
Zfish    36 KNDESSLQCSC----ENTNLCENNS-CW--------GRICF-YTSVHERVVRGCFQTAEQCYVP- 85

  Fly   176 RSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRVEEGRQISVQDYVPHRL 240
                          |.|    |.:..|.....||..|....|......||:..::.:...||
Zfish    86 --------------AIP----GVYTKCCYTHHCNANLTMPEKPVCLFSVEKPIRVILLVGVP--- 129

  Fly   241 TSWEFVAIILGATLFICFTGTSTW-----YYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDII 300
                 :.::|...:..|  |...|     .||...:...|   ..|..|..||      |..||.
Zfish   130 -----LLVLLVIAMAAC--GLVLWLRTRRQYCHPVEHDTS---MLKVPSGGDP------TYGDIF 178

  Fly   301 -EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFRE 364
             |..|||||: |||.||||::|||:.|...:||||:||||||.|.||:|||||||||:|.|||||
Zfish   179 DEFCTSGSGT-GLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRE 242

  Fly   365 AEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIA 429
            .|||.||.|||||||||||:|.....:.|||||||.:||.|||:|:|....:|....|.|.||||
Zfish   243 TEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIA 307

  Fly   430 TGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGT 494
            :||.|||.:|:.|:||||||||||||:|||||.|..|.|.||||||.|.:..|.:|:.:..||||
Zfish   308 SGLVHLHTEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYLDVGTNPRVGT 372

  Fly   495 KRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEE 559
            |||||||||||::....|:|||:.|::|.||:||||.||..:..|.:||:.|::|:|..|||.||
Zfish   373 KRYMAPEVLDETIRVDVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFDMVPSDPSFEE 437

  Fly   560 MKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVE-----DK 619
            ||||||:::.||::.||.|:..:|..:||:|||||:.:|.|||||||::|:|:.:..:     ||
Zfish   438 MKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSLSKLDQDHDYDIDK 502

  Fly   620 VK 621
            :|
Zfish   503 LK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	19/92 (21%)
		GS	294..324	CDD:197743	18/30 (60%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	171/286 (60%)
acvrl1	XP_021325397.1	TFP_LU_ECD_ALK1	39..103	CDD:467064	21/96 (22%)
		TGF_beta_GS	173..200	CDD:462503	16/27 (59%)
		Protein Kinases, catalytic domain	196..493	CDD:473864	176/296 (59%)