Protein Alignment CG13748 and APP

DIOPT Version :10

• Sequence 1: NP_610430.1
• Gene: CG13748 / 35896
• FlyBaseID: FBgn0033355
• Length: 113
• Species: Drosophila melanogaster
• Sequence 2: NP_000475.1
• Gene: APP / 351
• HGNCID: 620
• Length: 770
• Species: Homo sapiens
• Alignment Length: 53
• Identity: 24/53 - (45%)
• Similarity: 32/53 - (60%)
• Gaps: 0/53 - (0%)

  Fly    58 QFCLMPARKGVCRALIPRWRYDPEQKKCVEFKFGGCDGNENNFASYKDCMSTC 110
            :.|...|..|.|||:|.||.:|..:.||..|.:|||.||.|||.:.:.||:.|
Human   289 EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13748	NP_610430.1	Kunitz-type	57..112	CDD:444694	24/53 (45%)
APP	NP_000475.1	A4_EXTRA	24..188	CDD:128326
		GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	28..123
		CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217	131..189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..284
		Kunitz_ABPP-like	294..341	CDD:438650	22/46 (48%)
		OX-2. /evidence=ECO:0000269|PubMed:2649245	344..365
		APP_E2	366..548	CDD:463752
		Heparin-binding	391..423
		Heparin-binding	491..522
		Collagen-binding. /evidence=ECO:0000269|PubMed:8576160	523..540
		JMTM_Notch_APP	693..767	CDD:425406
		Interaction with PSEN1. /evidence=ECO:0000269|PubMed:30630874	695..722
		Basolateral sorting signal	724..734
		Interaction with G(o)-alpha	732..751
		Required for the interaction with KIF5B and for anterograde transport in axons. /evidence=ECO:0000269|PubMed:17062754	756..770
		YENPXY motif, contains endocytosis signal. /evidence=ECO:0000269|PubMed:10383380	757..762