DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13748 and APLP2

DIOPT Version :10

Sequence 1:NP_610430.1 Gene:CG13748 / 35896 FlyBaseID:FBgn0033355 Length:113 Species:Drosophila melanogaster
Sequence 2:NP_001633.1 Gene:APLP2 / 334 HGNCID:598 Length:763 Species:Homo sapiens


Alignment Length:99 Identity:34/99 - (34%)
Similarity:47/99 - (47%) Gaps:16/99 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 DLYDDVSDFFDAISLDDVANTGRNTHP---------------EQFCLMPARKGVCRALIPRWRYD 79
            ::.:|...::|....||. |....|.|               :..|...|..|.|||::|||.:|
Human   266 EVVEDRDYYYDTFKGDDY-NEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFD 329

  Fly    80 PEQKKCVEFKFGGCDGNENNFASYKDCMSTCEGM 113
            ..:.|||.|.:|||.||.|||.|...||:.|:.|
Human   330 LSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13748NP_610430.1 Kunitz-type 57..112 CDD:444694 26/54 (48%)
APLP2NP_001633.1 A4_EXTRA 42..204 CDD:128326
GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 46..139
CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 147..205
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..299 7/33 (21%)
Kunitz_ABPP-like 309..360 CDD:438650 25/50 (50%)
APP_E2 365..547 CDD:463752
JMTM_APLP2 680..760 CDD:411992
Interaction with DAB2. /evidence=ECO:0000250 749..763
NPXY motif 750..755
Blue background indicates that the domain is not in the aligned region.

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