DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and REXO4

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_065118.2	Gene:	REXO4 / 57109	HGNCID:	12820	Length:	422	Species:	Homo sapiens

Alignment Length:	441	Identity:	98/441 - (22%)
Similarity:	156/441 - (35%)	Gaps:	144/441 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 KSPSHTSQPNAVNNSPNG----------------RQKSWFP----LTFTMGINDQGEVQVQTQSD 863
            |.|:  |.|.||...|..                :|||..|    :...||...:.::..|.:.:
Human    47 KKPA--SGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKE 109

  Fly   864 AS---------SGK------------SEQEEETEKPPTK--GLDNNRMYALHAVVCQVDDGTQKN 905
            .|         :||            |:.:.....|.||  |.::|:            .||::.
Human   110 TSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNK------------KGTKER 162

  Fly   906 LVSLINVQRP--YHTMKLAESADDPQSQWYIFNDFSISPVSP-QESVWFTLDWKVPCILFYRHVE 967
            ....|..:|.  .|..:.|:.|               :|..| :|.:||
Human   163 TNGDIVPERGDIEHKKRKAKEA---------------APAPPTEEDIWF---------------- 196

  Fly   968 DDSESASTTSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQS 1032
            ||.:.|..              |::.|       |...:|....||......:|..::.......
Human   197 DDVDPADI--------------EAAIG-------PEAAKIARKQLGQSEGSVSLSLVKEQAFGGL 240

  Fly  1033 GDLVAMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVV 1097
            ...:|:|.|.|.:.|:..|              ...||:|.:...|..    ..|.|:...|.|.
Human   241 TRALALDCEMVGVGPKGEE--------------SMAARVSIVNQYGKC----VYDKYVKPTEPVT 287

  Fly  1098 DYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQII 1162
            ||.|..|||:|.:|      |:...|:...:::..::. |.|.|||.|.||.:|:.:..|.::|.
Human   288 DYRTAVSGIRPENL------KQGEELEVVQKEVAEMLK-GRILVGHALHNDLKVLFLDHPKKKIR 345

  Fly  1163 DTVHLFHMPHHRMV-----SLRFLAWHFLGTKIQSETHDSIEDARTTLQLY 1208
            ||..  :.|....|     |||.|:...||.::|...|.||:||:..::||
Human   346 DTQK--YKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLY 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	30/165 (18%)
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	53/178 (30%)
REXO4	NP_065118.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194		33/175 (19%)
REXO4	NP_065118.2	REX4_like	244..394	CDD:99847	51/176 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810