DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and Rexo5

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_648050.1	Gene:	Rexo5 / 38740	FlyBaseID:	FBgn0286051	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	122/555 - (21%)
Similarity:	196/555 - (35%)	Gaps:	198/555 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   837 RQKSWFPLTFTMGINDQ-------------GEVQVQTQSDASSGKSEQEEE------TEKPPTKG 882
            ::|....|...|.:||:             .||:|:.:|.|   |:|..::      :::.|...
  Fly    16 KKKKLAALANLMELNDRDRLHEAELAKKRDAEVEVEEKSTA---KAEDGDDGFIVVGSKRKPRNR 77

  Fly   883 LDNNRMYA--------------LHAVVCQVDDG-------------TQKNLVS---------LIN 911
            ..||.:.|              ::..:...|.|             .|.|.:|         |.|
  Fly    78 RQNNELEADSQTAPGTSDPEEPVNKKIRNYDAGGDSLPLEIGSLSEDQYNQLSAELRRRKRELEN 142

  Fly   912 VQRPYHTMKLAE-----SADDPQ-SQWYIF-NDF----------SISPVSPQE--SV--WFTLDW 955
            |.    .::|.|     |.:.|| ::..|| .|.          ..||..|..  ||  |.:|..
  Fly   143 VP----ALRLREMGQRASLETPQDARTPIFLTDIQNLLMCALIGQKSPCRPDRWCSVEKWLSLSH 203

  Fly   956 KVPCIL----FYRHVEDDSESASTTSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGN-- 1014
            .|..||    .|.::.::::..:|.....|:.|..:|       |.......::||....|.|
  Fly   204 SVVVILEGLSLYHYLSNETQFEATNRIFSTKLEMILP-------PQEEGQKIIDEIAKIPLTNAQ 261

  Fly  1015 ----------------LSADATL-----QPLQS-----------DEMPQS------------GDL 1035
                            |:.|.||     .|::|           |:.|::            |..
  Fly   262 ARRLIDEHGSLESAVELNKDPTLFVKTIFPIESSKSESDDMHEDDKFPRTKLLLSALQMVDEGYP 326

  Fly  1036 VAMDAEFVT-----------LNPEENEIRPDGKTATIKPCHM-----SVARISCIRGQGPAEGVP 1084
            :.:..|..|           ..|..|.....|  ...:.||.     .:.|||.:.
  Fly   327 IPLQGELHTRFQNFKFTKDLYAPVTNRSPMFG--VDCEMCHTEAGCNELTRISIVN--------- 380

  Fly  1085 FMDDYISTQE-------KVVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVG 1142
              ::|.:..|       ::.|||||:|||....::.  ..|||..::   :::..|:....|.||
  Fly   381 --ENYETVYETLVLPNNRITDYLTQYSGITAEIMEQ--VTKRLDVVQ---KEVSELLPPDAILVG 438

  Fly  1143 HGLKNDFRVINIYVPSEQIIDTVHLFHMP--HHRMVSLRFLAWHFLGTKIQS--ETHDSIEDART 1203
            ..|.:|...:.:..|  .:|||...|:..  ..|...|:.||..||...||.  :.||||||:|.
  Fly   439 QSLNSDLNAMKMMHP--YVIDTSVCFNTSGVRRRKTKLKDLAKTFLQEIIQENIDGHDSIEDSRA 501

  Fly  1204 TLQLYKHYLKLQEEKKFANALK---NLYERGKQLQ 1235
            ||:|.|        ||.||:::   .:..:.||||
  Fly   502 TLKLVK--------KKLANSIEFGDQILTQHKQLQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	32/174 (18%)
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	52/199 (26%)
Rexo5	NP_648050.1	REX1_like	357..507	CDD:99848	48/169 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810