DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8237 and fam8a1b

DIOPT Version :9

Sequence 1:	NP_610425.1	Gene:	CG8237 / 35891	FlyBaseID:	FBgn0033350	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001017551.1	Gene:	fam8a1b / 548347	ZFINID:	ZDB-GENE-050410-14	Length:	326	Species:	Danio rerio

Alignment Length:	344	Identity:	89/344 - (25%)
Similarity:	143/344 - (41%)	Gaps:	84/344 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GEQGEETGQKLTERSTKEAYFESLAEWAKQATLAQNAMLMFPYYL------------MANYPTMF 54
            |:|...|....||      |.|.|.||            |:.||.            ..::|..|
Zfish    32 GKQVNSTAVNTTE------YCEKLQEW------------MWQYYCSYMNWQSWIAMSALSFPPCF 78

  Fly    55 PGLPSSAALQAAAMGQ-----------------PQALVQGSAAAPGEPAAEP-RLPAPNFSGLRI 101
            |...::.:....|.|.                 |.|.|..:|.|.|:.:|.| ..||......:.
Zfish    79 PTQGATESHGTTAWGTDMSNGDLRNWLNNPFGFPAAAVNVAAPANGQSSAAPATAPAQILQQQQA 143

  Fly   102 LGEAAQLDIIQRLGGYEYVLSPFWKRAVAETIDMFILFIVKIIITFGVVNLFNI----EFDEDVI 162
            .|.|.|       .|.||.:....:|.:||.:|.||||.:|..|...:|:|..:    :|....|
Zfish   144 NGNAQQ-------PGREYSIPSPLQRFIAEMVDFFILFFIKATIIISIVHLSGMKDISKFAMHFI 201

  Fly   163 RRTLDQEDLFSNFFDTSLDFISMSTDLLLIEMLTKFIVCCYEALWTYLYQGATPGKSLMKIRIYY 227
            ...:|:        |||::.:.   .::|:.::.:.:||.||.:..:...||||||.|:.:|:..
Zfish   202 VEEIDE--------DTSMEELQ---KMMLVALVYRILVCFYEIICIWGAGGATPGKFLIGLRVVT 255

  Fly   228 VEAVMPLQGPPLPQFVLQPQREPMRALLYPPQTPSLMRSFARALIKNLGMTLLFPICVLMVFFKN 292
            .::.:.:|              |.|..:.|....:|..|..|||.||..:...||..:.::||::
Zfish   256 CDSSVLVQ--------------PNRVRVVPATNVTLSASTVRALNKNFSIAFFFPAFITLLFFQH 306

  Fly   293 NRTAYDVLTKTIVVESNSI 311
            |||.||::..||||:.:.:
Zfish   307 NRTVYDIVAGTIVVKRHRL 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8237	NP_610425.1	RDD	123..302	CDD:294483	51/182 (28%)
fam8a1b	NP_001017551.1	RDD	157..316	CDD:283845	51/183 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580497
Domainoid	1	1.000	50	1.000	Domainoid score	I11689
eggNOG	1	0.900	-	-		E1_KOG4647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5040
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1123503at2759
OrthoFinder	1	1.000	-	-		FOG0005417
OrthoInspector	1	1.000	-	-		otm26320
orthoMCL	1	0.900	-	-		OOG6_107529
Panther	1	1.100	-	-	LDO	PTHR13659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3819
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.830