Protein Alignment Gle1 and Gle1

DIOPT Version :10

• Sequence 1: NP_610400.1
• Gene: Gle1 / 35849
• FlyBaseID: FBgn0033316
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_061511417.1
• Gene: Gle1 / 1280670
• VectorBaseID: AGAMI1_012338
• Length: 706
• Species: Anopheles gambiae
• Alignment Length: 737
• Identity: 257/737 - (34%)
• Similarity: 392/737 - (53%)
• Gaps: 99/737 - (13%)

  Fly     1 MDDMMRAMDCLNMAATLRNAALASATCTGRTLGED------RE------PIWVEGSRKTPE--PP 51
            ::|::...|.:.::| |||||..|.....||:|.|      ||      |..|:.:..|.|  |.
Mosquito     9 IEDLLSGFDSMKLSA-LRNAAKLSPLIKERTIGPDCADLSRREVSITILPAAVDSNDTTKENDPN 72

  Fly    52 LPEESP--------APEPNNEIPLLPKI----DFEPNISCFPDLQAINASIVRRELEEEGKRCVR 104
            :..|.|        :.|.....|:.|:.    ..:|     .|..|:.:.:.::|||       |
Mosquito    73 VSNEGPSSIHGTPKSDEKKKSAPVTPQFTAIKHSDP-----ADCTAVQSKLHQQELE-------R 125

  Fly   105 QQL----KAIRDKQDAMRLS---RETQQRKE--------ERQRDQLQQKALRERNESLLIQKADQ 154
            |:|    ||:.::.:.:||:   ||.|..|.        .|:....:|:.|....|.   :|..|
Mosquito   126 QRLASVQKALAERHNKIRLADEQREAQLAKSLHEASLNVARKVQDSEQRLLHAVREQ---EKLAQ 187

  Fly   155 MTAAQLEAQQRE----------QLALRQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKILLSLNP 209
            ..|||.:||..|          ||..||:..::..:| :|.|.:...:|....|...|.|..:..
Mosquito   188 AAAAQRQAQMEEENKRLNDIQAQLKRRQEEMRRKAQL-IETVRQSIGQFRVGTETFTKALTVIGV 251

  Fly   210 ETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELDIIKQLAE 274
            :.......|...::.|.:.||||:..:. .|.|:..   ..:.:|.::|:.||.:.:::.:.||:
Mosquito   252 QHATKFTNQKKAIRALQKDFEQLLQGIN-ANQEVSQ---VEVDQAADYCRQLDQVNVEVTEILAQ 312

  Fly   275 FSEQIQQQLKMEAAKKLEDERQRQQQQEEERQKLEEQQKLEEQEKLRKEKEESAAKEKQQEAE-- 337
                      :||::|.:.|:.:|||.::::|:.::||:.:||.|:.:....:|.:...|:|:
Mosquito   313 ----------IEASQKQQQEQLQQQQLQQQQQQQQQQQQEQEQAKVAEAPAPAAQQPAVQQADSK 367

  Fly   338 -TAKADAANVPAPLEPKSQDV------PPAATATSTSVHPDRLKFYNDILALYQSKVDAVKPLQT 395
             |...|.::...|.:|.:|.|      .|        |.|:.|:|||:|.:.|:....|||.|..
Mosquito   368 PTDSTDGSSAAVPADPTAQAVDNEPFFQP--------VSPECLQFYNEIKSFYEQHQTAVKQLMD 424

  Fly   396 EESLKQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFFAGQPTKVMNGTITINDHPLARDYC 460
            :.|:|.||..||:|||:|:||||||:.:|....:.||.:..:||..|..:|.::||.|||.|.||
Mosquito   425 DPSMKTYRFNCQKAINVPVNAISAVNREHFIDKYSKLAALLSGQNVKAGDGMVSINGHPLGRTYC 489

  Fly   461 MLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYVIPQQQG 525
            .:|:|||||||.:|:|.||..||||.|::.:..|:..||||:.||||:::|.|:||||.:||.:|
Mosquito   490 TMLLAKKFVSQADTSISSNASAAFPVAAIAVALWQRFPDFGRFFLAYLHRECPYLVPYYLPQHEG 554

  Fly   526 QTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQGRKAAGPDECFELNEGWLWLA 590
            |:.|::|||:|||..|...|||.|.||||.:||||||||||::..||.........|..||.||.
Mosquito   555 QSQEEFLKTLGYRFADGGVLEKQDQYLKRMSGLARLYAAVIVTVPRKDDPTPHPHGLEYGWRWLT 619

  Fly   591 HMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGGPKTRLEML 655
            ::::..|.|||.||||.|.|||.|.||...|||||:|:|..:|..||..|...|.||||.|||.|
Mosquito   620 NILNRFPQPDICATLIAEFLQTAGSELHAAYGKQFLKVLRVLQGDYMSALNRIDTGGPKARLEGL 684

  Fly   656 LAKFLRERQIAQAVGVLPPGFW 677
            :||.|.|.:|.:..|::...||
Mosquito   685 IAKILTEGRIERPEGIMSVNFW 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gle1	NP_610400.1	Smc	<82..>232	CDD:440809	43/174 (25%)
		EnvC	104..>365	CDD:443969	71/294 (24%)
		GLE1	394..633	CDD:462280	122/238 (51%)
Gle1	XP_061511417.1	None