Protein Alignment Cyp4e2 and CYP4F11

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_067010.3
• Gene: CYP4F11 / 57834
• HGNCID: 13265
• Length: 524
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 161/548 - (29%)
• Similarity: 270/548 - (49%)
• Gaps: 75/548 - (13%)

  Fly     2 WFVLYI----FLALPLLLVAYLELSTFRRRRVL------NKFNGPRGLPLMGNAHQMGKNPSEIL 56
            |.:|.:    :|...:|...|......||.:..      |.|.|.:|  |:....:..|..::::
Human    19 WLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQG--LVTPTEEGMKTLTQLV 81

  Fly    57 DTVFSWWHQYGKDNFVFWIG-TYSNVLVTSSKYLEFILSSQTLITKSDI--YQLTHPWLGLGLLT 118
            .|.        ...|..|:| |:..:::.....:..|.|:...:...|:  |....||||.|||.
Human    82 TTY--------PQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLL 138

  Fly   119 STGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK---TVAAGDNIFDFQEQAHYLTLD 180
            |.|.||.:||:|:|||||||||:.:.::.|::..  |.|.|   ..:.|....|..|....:|||
Human   139 SGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVN--IMHDKWQRLASEGSARLDMFEHISLMTLD 201

  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQD 245
            .:.........|..| :.|..:.|..::...:..|....|...:.||.|.||...:.|....:.|
Human   202 SLQKCVFSFESNCQE-KPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHD 265

  Fly   246 FTNEIIAKRIEAHKSGAVSTNAGDEFTRKK-----MAFLDT-LLSSTIDGRPLNSKELYEEVSTF 304
            ||:.:|.:|     ...:.|...|:|.:.|     :.|:|. |||...||:.|:.:::..|..||
Human   266 FTDAVIQER-----RCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTF 325

  Fly   305 MFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQ 369
            ||||||||.||:|:.:|.|::|.:.|.:..:|.:|::.:.| ..:..:.:::|:.:|.:.|||:.
Human   326 MFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDRE-PIEIEWDDLAQLPFLTMCIKESL 389

  Fly   370 RVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE---LEKPG 430
            |::|.||.|.|...:|:|: ||.::|||....:.::.:.||..|:.||..:.|.||:   :::..
Human   390 RLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERS 454

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKR 495
            |..::||||||||||||.||:.|:|.|::..:.:|.:||...|                 .|:|.
Human   455 PLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTE-----------------PRRKP 502

  Fly   496 DPYRHKYDPILSAVLTLKSENGLYIRLK 523
            :             |.|::|.||::|::
Human   503 E-------------LILRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	146/467 (31%)
CYP4F11	NP_067010.3	CYP4F	74..515	CDD:410772	148/487 (30%)