Protein Alignment Cyp4e2 and Cyp12a5

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 117/504 - (23%)
• Similarity: 220/504 - (43%)
• Gaps: 94/504 - (18%)

  Fly    54 EILDTVFSWWHQYGKDNFVF---WIGTYSNVLVTSSKYLEFILSSQTL---------------IT 100
            |:::.:.:....||  |.:|   .:|....|:..:.|..|.:..::.:               :.
  Fly    73 EMMEMIDALRQDYG--NIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVY 135

  Fly   101 KSDIYQLTHPWLGL-GLLTSTGSKWHKHRKMITPAF--HFNILQDFHEV--MNENSTKFIKHLKT 160
            :.|.:.      |: |::.|.|..|...|.::.|..  ..|:...|.::  :|:...:.||.::.
  Fly   136 RKDFFD------GVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRD 194

  Fly   161 VAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAM--ENRSSSIVQAFKDMCYNINMRAFHPLKRN 223
            .:..:...:|.|..:..||:.:...|:...:..:  ..::|...:.||.:.......|...:|.:
  Fly   195 ASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPS 259

  Fly   224 ELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIE----AHKSGAVSTNAGDEFTRKKMAFLDTLLS 284
            ...|...|......||:.::|:.|.:.:.:.||    ..|.|.|.       ...:.:.|:.||.
  Fly   260 LWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVR-------PEHEQSVLEKLLK 317

  Fly   285 STIDGRPLNSKELYEEVSTFM-----FEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNS 344
              :|          ::|:|.|     ..|.|||:|..:..:..|:::.::|.:|.:|..:|:.|
  Fly   318 --VD----------KKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPN- 369

  Fly   345 ELGRDATFQEIS--QMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLG 407
               :|:.|.|.|  .:.||...|||:|||||.|....|...:|.||.|..||.||.:::..:...
  Fly   370 ---KDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSL 431

  Fly   408 YNEKVFKDPHKFRPERF--------------ELEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVV 458
            |:|:.|..|.:|.|||:              :|:...||.::||..|||.|:|::...:|::...
  Fly   432 YSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGT 496

  Fly   459 SKIIRNFEVLPALDEL--VSKDGYISTTIGLPDAERKKRDPYRHKYDPI 505
            :::||||.|     |.  .:|:.:.|..|.||:.      |.:.|:..:
  Fly   497 ARLIRNFNV-----EFNHSTKNAFRSALINLPNI------PLKFKFTDV 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	114/490 (23%)
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	115/487 (24%)