Protein Alignment Cyp4e2 and Cyp24a1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_963966.1
• Gene: Cyp24a1 / 25279
• RGDID: 2462
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 501
• Identity: 131/501 - (26%)
• Similarity: 223/501 - (44%)
• Gaps: 99/501 - (19%)

  Fly    21 LSTFRRRRVLNKFNGPRGLPLMGNAHQM----GKNPSEILDTVFSWWHQYGKDNFVFWIGTYSNV 81
            |.|....|.:....||...||:|:..::    |.....  ||:..:..:||: .|...:|::.:|
  Rat    46 LMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQH--DTLAEYHKKYGQ-IFRMKLGSFDSV 107

  Fly    82 LVTSSKYLEFILSS-----QTLITKSDIYQLTHPWL--------GLGLLTSTGSKWHKHRKMITP 133
            .:.|...||.:..:     |.|..|        ||.        ..||:...|.:|.:.|.
  Rat   108 HLGSPSLLEALYRTESAHPQRLEIK--------PWKAYRDHRNEAYGLMILEGQEWQRVRS---- 160

  Fly   134 AFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGV-SINAMENR 197
            ||...:::.. |:|     |..|.:..|.|     ||.|:     :|.:||....: .:.:..|:
  Rat   161 AFQKKLMKPV-EIM-----KLDKKINEVLA-----DFLER-----MDELCDERGRIPDLYSELNK 209

  Fly   198 SSSIVQAFKDMCYNINMRAFHPLKR---NELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHK 259
            .|     |:.:|..:..:.|..|::   .|.|        .:...:||:.....:::...:|.||
  Rat   210 WS-----FESICLVLYEKRFGLLQKETEEEAL--------TFITAIKTMMSTFGKMMVTPVELHK 261

  Fly   260 SGAVSTNAGDEFTRKKMAFLDTLLSST---IDGR--------------------PLNSKELYEEV 301
              .::|......|   :|: ||:..|.   ||.|                    .|:.||||..|
  Rat   262 --RLNTKVWQAHT---LAW-DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAV 320

  Fly   302 STFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIK 366
            :.......:||.:.:.:.:|.|||:...||:|.:|.:.|:.:::..|   .:::..|.||...:|
  Rat   321 TELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR---AEDLRNMPYLKACLK 382

  Fly   367 EAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERF--ELEKP 429
            |:.|:.|||||..|..:|..|:....:||||.|.|...:||.:|..|:|.|||||||:  :.:|.
  Rat   383 ESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 447

  Fly   430 GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV 475
            .||.::||..|.|.|||::.|.|::...:..||:.::::...:|.|
  Rat   448 NPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	118/450 (26%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	120/455 (26%)