Protein Alignment Cyp4e2 and Cyp4a29

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001093653.1
• Gene: Cyp4a29 / 230639
• MGIID: 3717143
• Length: 509
• Species: Mus musculus
• Alignment Length: 535
• Identity: 157/535 - (29%)
• Similarity: 255/535 - (47%)
• Gaps: 58/535 - (10%)

  Fly     3 FVLYIFLALPLLLVAYLELSTFRRR----RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWW 63
            |:..||| :.|||:.:.....:.||    |.|.:|..|....|.|:..|..      :|....|.
Mouse    18 FLQVIFL-IGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQFK------VDEELRWI 75

  Fly    64 HQYGK---DNFVFWI-GTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKW 124
            .:|.:   ..|:.|| |::..:.|....|::.||....  .|:.:|:...||||.||....|.:|
Mouse    76 LRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRAD--PKASLYRFLTPWLGHGLFFLNGDEW 138

  Fly   125 HKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGV 189
            .:||:::|||||::||:.:..:|.::....::..:.:|..|...:.......:.||.|...|...
Mouse   139 FQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLMMLDTIMKYAFSY 203

  Fly   190 SINAMENRSS-SIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAK 253
            ..:...:||| :.:||..|:...:..|..:....|:::|.|.    ::||...:.....:|...:
Mouse   204 QGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLT----SHSRRTNSACQIAHEHTDR 264

  Fly   254 RIEAHKSGAVSTNAGDEFTRKK-MAFLDTLLSSTI-DGRPLNSKELYEEVSTFMFEGHDTTTSGV 316
            .::..|:......:..:...|: :.|||.||.|.: ||..|:.|.|..||.:.||.||||..||:
Mouse   265 VVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMFGGHDTPASGI 329

  Fly   317 SFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRF 381
            |:..|.|:.|.|.|::..:|.:.::|:   |...|:..:.||.|..:.||||.|:||.:|.:||.
Mouse   330 SWVFYALATHPDHQQRCREEVQSLLGD---GSPITWDHLHQMPYTTMCIKEALRLYPPIPSVGRK 391

  Fly   382 TEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEK-PGPFEYVPFSAGPRNC 444
            ....... ||..:|||.|:.|....|.:|.||:.:|..|.|.||.:.. .....::|||.|.|||
Mouse   392 LSTPVTFPDGRSLPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNSVQHSHAFLPFSGGSRNC 456

  Fly   445 IGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAV 509
            ||:..|:..:|..|:..:..||:||                          ||.|   .||.:..
Mouse   457 IGKHLAMNVLKVAVALTLLRFELLP--------------------------DPSR---VPIPTQQ 492

  Fly   510 LTLKSENGLYIRLKE 524
            |.|||:||:|:.|::
Mouse   493 LVLKSKNGIYLHLRK 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	136/460 (30%)
Cyp4a29	NP_001093653.1	CYP4B-like	75..504	CDD:410771	138/466 (30%)