Protein Alignment Cyp4e2 and Tbxas1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_035669.3
• Gene: Tbxas1 / 21391
• MGIID: 98497
• Length: 533
• Species: Mus musculus
• Alignment Length: 583
• Identity: 127/583 - (21%)
• Similarity: 220/583 - (37%)
• Gaps: 126/583 - (21%)

  Fly     4 VLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVF---SWW-- 63
            |....|...|.|:.:..:|.|.|...|. ...|:..|.:||             .:|   .:|
Mouse    16 VTVTLLVALLALLKWYSMSAFSRLEKLG-IRHPKPSPFVGN-------------LMFFRQGFWES 66

  Fly    64 -----HQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQ------LTHPWLGLGLL 117
                 .:|| ....:::|...:|:::....::     |.|:.....:.      |....:...:|
Mouse    67 QLELRERYG-PLCGYYLGRRMHVVISEPDMIK-----QVLVENFSNFSNRMASGLEPKMVADSVL 125

  Fly   118 TSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182
            .....:|.:.|..:..:|....|.:...::::.....:.|||..||..:.|:.|......|:||:
Mouse   126 LLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVV 190

  Fly   183 CDTAMGVSINAMENRSSSIVQ-------------------AFKDMCY-------NINMRA----F 217
            ...|.|..:::..:.....||                   :|..:..       |.|...    |
Mouse   191 ASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFF 255

  Fly   218 HPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTL 282
            :.|.||.:..|   |..|..   :..:||...::..:   |...:|.....|...       ::|
Mouse   256 NTLIRNVIALR---DQQAAE---ERRRDFLQMVLDAQ---HSMNSVGVEGFDMVP-------ESL 304

  Fly   283 LSS------------TIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFK 335
            .||            |...:|....|:..:...|:..||:..|:.:||..|||:.|.|.|.:|.|
Mouse   305 SSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLK 369

  Fly   336 EQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLN 400
            |....||........:.||  .:.|||:.|.|..|:||......|...:|..:.|..:|.||.|.
Mouse   370 EVDLFMGKHPAPEYHSLQE--GLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLE 432

  Fly   401 LGLVMLGYNEKVFKDPHKFRPERFELE---KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKII 462
            :.:..|.::.:.:.:|..|.||||..|   :..||.|:||.||||:|:|.:..||.:|..:.:::
Mouse   433 IAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVL 497

  Fly   463 RNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKER 525
            ..|..                     :|..:.:.|.:      |.:...|..:||:||::..|
Mouse   498 HKFRF---------------------EASPETQVPLQ------LESKSALGPKNGVYIKIVSR 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	108/502 (22%)
Tbxas1	NP_035669.3	cytochrome_P450	74..527	CDD:477761	110/503 (22%)