Protein Alignment Cyp4e2 and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 498
• Identity: 129/498 - (25%)
• Similarity: 221/498 - (44%)
• Gaps: 86/498 - (17%)

  Fly    15 LVAYLELSTFRRRRVLNKFNGPRGLP------LMGNAH-------QMGKNPSEILDTVFSWWH-- 64
            ::.::..|.:||..:. |.....|:|      |.||.:       ::|.|     ||  :.||
 Worm    13 IITFISYSIWRRHAIF-KLRSSIGIPGPPVHWLWGNLNIIKDRVSRLGYN-----DT--TQWHPT 69

  Fly    65 ---QYGKDNFVFWIGTYSNVLVTSSKYLE--FILSSQTLITK--SDIYQLTHPWLGLGLLTST-G 121
               :|| ..|..:.||..::.|:..:.::  ||.:......:  .||:.:..  |...||.:| .
 Worm    70 LHTKYG-PIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQ--LNQSLLQNTYA 131

  Fly   122 SKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTA 186
            :.|...|..|.|.|....::..||.:......|::.||..::....:|..|....|:||:|...|
 Worm   132 TGWKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWDIFENFQSLSLDIIGKCA 196

  Fly   187 MGVSINAMENRSSSIVQAFKDMCYNINMRAF---HPLKRN----------------ELLYRLAPD 232
            ..:..|...:|:        |:.| :..|.|   ..||::                ..||:.:..
 Worm   197 FAIDSNCQRDRT--------DLFY-VQARKFVGAVDLKKSWILPVSLILPELSWLWRFLYKFSDL 252

  Fly   233 YPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKEL 297
            ..|....:|.|.|     :..|..|.:.|..||:           .|:.|:.....|: :..:|:
 Worm   253 SAAELPLVKGLVD-----LYDRRRAGEGGNDSTD-----------LLNLLIRRETIGK-MTQREV 300

  Fly   298 YEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLD 362
            .|....|:..|::||::.:.|:.|||:.:...|:||::|.::...|:.|..|:    |..|||||
 Worm   301 IENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTKENAGLNYDS----IHNMKYLD 361

  Fly   363 LFIKEAQRVY-PSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFE- 425
            ...||:.|.| |:..|..|....|..|.|.:.|:.:||.:....:..|...::.|.:|:|||||
 Worm   362 CVYKESLRFYPPTTHFTNRVCLNDMTIRGQIYPEDSTLKVQPYTIHRNPANWESPDEFQPERFEN 426

  Fly   426 -LEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467
             .||....:::||..|||.|:|.:||.:|.||.::|::..||:
 Worm   427 WEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFEL 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	112/427 (26%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	114/430 (27%)