Protein Alignment Cyp4e2 and CYP19A1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 122/506 - (24%)
• Similarity: 216/506 - (42%)
• Gaps: 120/506 - (23%)

  Fly    11 LPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFVFWI 75
            :|:||:..|.|..:       .:.|...:|  |..:.||..|      :.|    :|:   ..|:
Human    26 MPVLLLTGLFLLVW-------NYEGTSSIP--GPGYCMGIGP------LIS----HGR---FLWM 68

  Fly    76 GTYSNVLVTSSKYLEF----ILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWH--KHRKMITPA 134
            |..|.....:..|.||    |...:|||                 ::.:.|.:|  ||.
Human    69 GIGSACNYYNRVYGEFMRVWISGEETLI-----------------ISKSSSMFHIMKHN------ 110

  Fly   135 FHFNI-------LQ--DFHE---VMNEN-----STK--FIKHLK--------TVAAG------DN 166
             |::.       ||  ..||   :.|.|     :|:  |:|.|.        ||.|.      |.
Human   111 -HYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDR 174

  Fly   167 IFDFQEQAHY---LTL--DVICDTAMGVSINAMENRSSSIV--QAFKDMCYNINMRAFHPLKRNE 224
            :.:...::.|   |||  .|:.||:..:.:....:.|:.:|  |.:.|....:       |.:.:
Human   175 LEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL-------LIKPD 232

  Fly   225 LLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDG 289
            :.::::..|..|.:::|.|:|....:||:     |...:||   :|...:.|.|...|:.:...|
Human   233 IFFKISWLYKKYEKSVKDLKDAIEVLIAE-----KRRRIST---EEKLEECMDFATELILAEKRG 289

  Fly   290 RPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQE 354
             .|..:.:.:.:...:....||.:..:.|.::|:::|.:.:..:.||.:.|:|.    ||....:
Human   290 -DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE----RDIKIDD 349

  Fly   355 ISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTT--LNLGLVMLGYNEKVFKDPH 417
            |.::|.::.||.|:.|..|.|..:.|...:|.||||..|.|||.  ||:|.:   :..:.|..|:
Human   350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM---HRLEFFPKPN 411

  Fly   418 KFRPERFELEKPGPFEYV-PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467
            :|..|.|  .|..|:.|. ||..|||.|.|:..|::.:|.::..::|.|.|
Human   412 EFTLENF--AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	109/449 (24%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	107/438 (24%)