Protein Alignment Cyp4e2 and CYP4B1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 167/539 - (30%)
• Similarity: 258/539 - (47%)
• Gaps: 76/539 - (14%)

  Fly     7 IFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71
            :.|.|..|.:.:|.|......:.::||.||....|.|:|.::.:..|  ||.|.||.||:...:
Human    20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGS--LDKVVSWAHQFPYAH- 81

  Fly    72 VFWIGTYSNVL-VTSSKYLEFILSSQTLITKS-DIYQLTHPWLGLGLLTSTGSKWHKHRKMITPA 134
            ..|.|.:...| :....|.:.:.|...  .|: |:|.....|:|.|||...|.||.:|||::||.
Human    82 PLWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPG 144

  Fly   135 FHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--C-----DTAMGVSIN 192
            ||:::|:.:..|..|::...:...:..|.....||......::.|:.:  |     ||.:|
Human   145 FHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLG---- 205

  Fly   193 AMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEA 257
              .:|.||...|..|:...:..|.......|:.:|.|.|....:.|..:...|.|:::|.:|..|
Human   206 --HSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAA 268

  Fly   258 HKSGAVSTNAGDEFTRKK------MAFLDTLLSS-TIDGRPLNSKELYEEVSTFMFEGHDTTTSG 315
            .:         ||..|||      :.|||.||.: ..|...|:..:|..||.|||||||||||||
Human   269 LQ---------DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSG 324

  Fly   316 VSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ--EISQMKYLDLFIKEAQRVYPSVPFI 378
            :|:.:|.::.:.:.|.:..:|.||::|:.:.     ||  ::.:|.||.:.|||:.|:||.||.:
Human   325 ISWFLYCMALYPEHQHRCREEVREILGDQDF-----FQWDDLGKMTYLTMCIKESFRLYPPVPQV 384

  Fly   379 GRFTEKDYV-IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELE---KPGPFEYVPFSA 439
            .|...|... :||..:|.|:.:::.:..|..|..|:.||..|...||..|   |..||.::||||
Human   385 YRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449

  Fly   440 GPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDP 504
            ||||||||:||:.|:|.|.:..:..||.                          ..||.|.   |
Human   450 GPRNCIGQQFAMSEMKVVTAMCLLRFEF--------------------------SLDPSRL---P 485

  Fly   505 ILSAVLTLKSENGLYIRLK 523
            |....|.|:|:||.::.||
Human   486 IKMPQLVLRSKNGFHLHLK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	145/473 (31%)
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	152/486 (31%)