Protein Alignment Cyp4e2 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 161/533 - (30%)
• Similarity: 260/533 - (48%)
• Gaps: 68/533 - (12%)

  Fly     9 LALPLLLVAYLELSTFRR--RRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNF 71
            |.|.|||:..::|...|:  .:.|.:|..|....|.|:..::.::  :.|..:..|...: ....
Human    25 LILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQD--QELQRIQKWVETF-PSAC 86

  Fly    72 VFWI-GTYSNVLVTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSKWHKHRKM 130
            ..|: |....|.:....|::.||.      :||     .|:...||:|.|||...|..|.:||:|
Human    87 PHWLWGGKVRVQLYDPDYMKVILG------RSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRM 145

  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--CDTAMGVSINA 193
            :|||||::||:.:..:|.::....:...:.:...|:..:..:....:|||.|  |..:...||.
Human   146 LTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ- 209

  Fly   194 MENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEII-AKRIEA 257
            ::..|.|.:||..|:...:..|..:...:|:.:|.|........|..:.....|:::| .::.:.
Human   210 VDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQL 274

  Fly   258 HKSGAVSTNAGDEFTRKK-MAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTSGVSFAV 320
            .|.|.:     ::..||: :.|||.||.:.:: |..|:.|:|..||.||||||||||.||:|:.:
Human   275 QKEGEL-----EKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL 334

  Fly   321 YLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKD 385
            |.|:.|...|.:..:|...::|:   |...|:..:.||.|..:.||||.|:||.||.|||.....
Human   335 YALATHPKHQERCREEIHSLLGD---GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTP 396

  Fly   386 YVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFE----YVPFSAGPRNCI 445
            ... ||..:|||..:.|.:..|.:|.||:.:|..|.|.||   .||..:    ::|||.|.||||
Human   397 VTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF---APGSAQHSHAFLPFSGGSRNCI 458

  Fly   446 GQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVL 510
            |::||:.|:|...:..:..||:||                          ||.|   .||..|.|
Human   459 GKQFAMNELKVATALTLLRFELLP--------------------------DPTR---IPIPIARL 494

  Fly   511 TLKSENGLYIRLK 523
            .|||:||:::||:
Human   495 VLKSKNGIHLRLR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	145/467 (31%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	146/478 (31%)