Protein Alignment Cyp4e2 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 137/526 - (26%)
• Similarity: 245/526 - (46%)
• Gaps: 82/526 - (15%)

  Fly     2 WFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGN--AHQMG--KNPSEILDTVFSW 62
            |.:|.:.|.| |.|........|:|..:    .||..|||:||  :::.|  |..:|.
Human    12 WLLLAVSLVL-LYLYGTRTHGLFKRLGI----PGPTPLPLLGNVLSYRQGLWKFDTEC------- 64

  Fly    63 WHQYGKDNFVFWIGTYSNVL----VTSSKYLEFILSSQTLITKSDIYQL--THPWLG-LGLLTST 120
            :.:|||    .| |||...|    :|....:      :|::.| :.|.:  ....|| :|.:.|.
Human    65 YKKYGK----MW-GTYEGQLPVLAITDPDVI------RTVLVK-ECYSVFTNRRSLGPVGFMKSA 117

  Fly   121 GS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLD 180
            .|     :|.:.|.:::|.|....|::...::.:.....:::|:..|........::.....::|
Human   118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMD 182

  Fly   181 VICDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYR-LAPDYPAYSRTLKTLQ 244
            ||..|:.||:|:::.|.....|::.|..   :......||..:.:|:. |.|.:.|.:.:|  ..
Human   183 VITGTSFGVNIDSLNNPQDPFVESTKKF---LKFGFLDPLFLSIILFPFLTPVFEALNVSL--FP 242

  Fly   245 DFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSS-----TIDGRPLNSKELYEEVSTF 304
            ..|...::|.:...|...:     ::..:.::.||..::.|     |...:.|:..||..:...|
Human   243 KDTINFLSKSVNRMKKSRL-----NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302

  Fly   305 MFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQ 369
            :|.|::||:|.:||.:|.|:.|.|.|:||.||...|:.|.   ...|:..:.||:|||:.:.|..
Human   303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK---APPTYDAVVQMEYLDMVVNETL 364

  Fly   370 RVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPG--PF 432
            |::|....:.|..:||..|:|..:|||:.:.:....|.::.|.:.:|.:||||||..:|..  |:
Human   365 RLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429

  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV---------------------S 476
            .|.||..|||||||.:|||:.:|..:.::::||...|..:..:                     |
Human   430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494

  Fly   477 KDGYIS 482
            :||.:|
Human   495 RDGTLS 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	117/456 (26%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	115/448 (26%)