Protein Alignment Cyp4e2 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 163/550 - (29%)
• Similarity: 270/550 - (49%)
• Gaps: 82/550 - (14%)

  Fly     4 VLYIFLALPLLLVAYLELS-----TFRRRRVLNKFNGPRGLPLMGN-----AHQMG-KNPSEILD 57
            :|::...|..||:.:|.|.     |.||.|...:  .||...|:|:     .::.| ::..::||
Human    28 LLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQ--PPRRNWLLGHLGMYLPNEAGLQDEKKVLD 90

  Fly    58 TVFSWWHQYGKDNFVFWIGTYSNVLV-TSSKYLEFILSSQTLITKSD--IYQLTHPWLGLGLLTS 119
            .:    |..    .:.|:|....:|| ....|::.:|.:...|...|  .|....||||.|||.|
Human    91 NM----HHV----LLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLS 147

  Fly   120 TGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLK--TVAAGDNI-FDFQEQAHYLTLDV 181
            .|.||.:||:::||||||:||:.:.::.|:::.  |.|.|  .:|.|..: .|..|....:|||.
Human   148 KGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD--IMHAKWRHLAEGSAVSLDMFEHISLMTLDS 210

  Fly   182 ICDTAMGVSINAMENRS---SSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTL 243
            :.......:.|..|..|   |:|:: ...:......|..|.|   :.:|..:.|...:.:....:
Human   211 LQKCVFSYNSNCQEKMSDYISAIIE-LSALSVRRQYRLHHYL---DFIYYRSADGRRFRQACDMV 271

  Fly   244 QDFTNEIIAKRIEA-HKSGA---VSTNAGDEFTRKKMAFLDT-LLSSTIDGRPLNSKELYEEVST 303
            ..||.|:|.:|..| .:.||   :....|     |.:.|:|. ||:...||:.|:.:::..|..|
Human   272 HHFTTEVIQERRRALRQQGAEAWLKAKQG-----KTLDFIDVLLLARDEDGKELSDEDIRAEADT 331

  Fly   304 FMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEA 368
            |||||||||:||:|:.::.|:::.:.|.|..:|.:|||...|| .:..:.:::|:.:..:.|||:
Human   332 FMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGREL-EELEWDDLTQLPFTTMCIKES 395

  Fly   369 QRVYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP--- 429
            .|.||.|..:.|...:|..: ||.::|||....:.:....:|..|:.|...:.|.||:.:.|
Human   396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQR 460

  Fly   430 GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERK- 493
            .|..||||||||||||||.||:.|::.||:..:..|.:                   ..|..||
Human   461 SPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL-------------------SVDRTRKV 506

  Fly   494 KRDPYRHKYDPILSAVLTLKSENGLYIRLK 523
            :|.|           .|.|::||||:::::
Human   507 RRKP-----------ELILRTENGLWLKVE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	145/470 (31%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	148/490 (30%)