Protein Alignment Cyp4e2 and cyp26c1

DIOPT Version :10

• Sequence 1: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_031761583.1
• Gene: cyp26c1 / 100489980
• XenbaseID: XB-GENE-1219115
• Length: 608
• Species: Xenopus tropicalis
• Alignment Length: 585
• Identity: 120/585 - (20%)
• Similarity: 197/585 - (33%)
• Gaps: 178/585 - (30%)

  Fly     9 LALPLLLVAYLEL------STFRRRRVLNKFNGPRGLPLMGNA-HQMGKNPS------EILDTVF 60
            |:|.|||.|..:|      ||..|...|....|..|.|..|.. |.:.:..|      |....:|
 Frog    20 LSLVLLLAASHQLWSLRWHSTRDRGSSLPLPKGSMGWPFFGETLHWLVQGSSFHSSRREKYGNIF 84

  Fly    61 SWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWH 125
            . .|..||          ..:.||.::.:..||..:..:..:...|.|...||...|:::..:.|
 Frog    85 K-THLLGK----------PVIRVTGAENIRKILLGEHHLVSTQWPQSTQIILGSNTLSNSIGELH 138

  Fly   126 KH-RKMITPAFHFNILQDF----HEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDT 185
            :. |||::.......|:.:    ||.:......:.:.:..|:       ....|..||..:....
 Frog   139 RQKRKMMSKVLSSAALESYLPRIHEAVRWEVRSWCRGVGPVS-------MLSCAKALTFRIAARI 196

  Fly   186 AMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLK------TLQ 244
            .:|:|:...:         |:::     .|.|..|..|  |:.|..|.| :|...|      ||.
 Frog   197 LLGLSLTDTQ---------FQEL-----TRTFEQLVEN--LFCLPLDIP-FSGLRKGMKARDTLH 244

  Fly   245 DFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEG 308
            .:..|.|.:::......|...            .||.|::|..: |:.:|.:||.|.....:|..
 Frog   245 QYMEEAIKEKLSKRDPDACED------------ALDYLINSAKEGGKEINMQELKESAIELIFAA 297

  Fly   309 HDTTTSGVSFAVYLLSRHQDEQRKLFKEQRE---------------------------------- 339
            ..||.|..:..|.||.:|.....|:.:|...
 Frog   298 FLTTASASTSLVLLLLKHPSAIHKIRQELASHGLSEHCEQCLPATENPNNNILQDNGHQCLTAGC 362

  Fly   340 ----VMG-----------NSELGRDATFQE----------------------------------- 354
                |||           ..:|..|.|.|:
 Frog   363 QLPLVMGTEGQVKTLWEQTKQLLTDRTDQDPQNSLSSKNLVNGENRIQEAPCSHDKSNCSPVPGK 427

  Fly   355 ------------------ISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNL 401
                              :..:.|||..:||..|:.|.|....|...:.:.:||..:|||.::..
 Frog   428 LQNSVFEGTCQQNISLEKLKSLHYLDCVVKEVLRLLPPVSGGYRTALQTFELDGYQIPKGWSVMY 492

  Fly   402 GLVMLGYNEKVFKDPHKFRPERFELE----KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKII 462
            .:........|:::...|.||||..|    |.|.|.|:||..|.|:|||::.|.:.:|.:..:::
 Frog   493 SIRDTHETAAVYQNAEMFDPERFSTERDEGKLGRFNYIPFGGGARSCIGKELAQIILKILAMELV 557

  Fly   463  462
             Frog   558  557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	99/513 (19%)
cyp26c1	XP_031761583.1	cytochrome_P450	59..588	CDD:477761	106/546 (19%)