DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut1 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	499	Identity:	128/499 - (25%)
Similarity:	208/499 - (41%)	Gaps:	70/499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSQKPRWGNL----LLLVALATTFGGAVSTGYCIGVINAPSKLMKVWCNQTLHDTYGSNLSAGGL 89
            |.::.|.|.|    :.|...|...|. .|.||.:...:.....:|:..:..||           |
Mouse    23 PGERERAGALKNRRVFLATFAAVLGN-FSFGYALVYTSPVIPELKLSSDPALH-----------L 75

  Fly    90 DLLW-SCVVSVFLVGGAIGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVEMLVIG 153
            |.:. |...|||.:|.|.|.|......:..|||...:.......:|   :.....|..:.||::|
Mouse    76 DKIQASWFGSVFTLGAAAGGLSAMLLNDLLGRKLSIMFSAVPSAIG---YAIMAGARGLWMLLLG 137

  Fly   154 RFVVGLASGLVTATLPMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDL----- 213
            |.:.|.|.||..|.:|:|:||:||..:||.||.              ...|..|||:..|
Mouse   138 RMLTGFAGGLTAACIPVYVSEIAPPDVRGALGA--------------TPQLMAVFGSLSLYALGL 188

  Fly   214 ---WHYALTAYMFLILVCYLPSYLFPESPKFLYIVKGNRAAAKRELQRLRGKDAEELIAQEMAEM 275
               |.:...|....:|:..|.....|.||:||.    :::..:..||.|....|:..:..|..::
Mouse   189 LLPWRWLAVAGEGPVLIMILLLSFMPNSPRFLL----SKSRDEEALQALTWLRADSEVHWEFEQI 249

  Fly   276 EAESNAKVQTS--SFCDVLRDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQ 338
              :.|.:.|:|  |:.:. |:||:..|::|.......|||:||..|..|..:||:...:.....|
Mouse   250 --QDNVRRQSSRVSWAEA-REPRVYRPVLIAVLMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQ 311

  Fly   339 WANLGAGCLNLAVSLLGPWLMAKCNRRTLMMFSCALCSVFLFTIAFVLFYIDQ------------ 391
            .|.: .|.:.|...|:....|....|:.|:..|.::......|:...:.::.:
Mouse   312 DAAI-VGAVRLLSVLIAAVTMDLAGRKVLLYVSASVMFAANLTLGLYVQFVPRPLTPNSTVEIVT 375

  Fly   392 -----VSWFAIACIVCIMGYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGI 451
                 .::..:..::..|.:|..|..|.|||.:.:.:|:..:..|.||..:..|.||...|::..
Mouse   376 LGDTAFNYLTLIPLLATMLFIMGYAMGWGPITWLLMSEVLPLRARGVASGLCVLVSWLTAFVLTN 440

  Fly   452 SFPLLQNAWGAFV-FLPFSITCVLLFLLTKFYLPETRGRDPSEV 494
            .|.|..||:|..| |..||..|:|..|.|...:||||||...::
Mouse   441 YFLLAVNAFGLQVPFFFFSAICLLSLLFTGCCVPETRGRSLEQI 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	120/469 (26%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	106/413 (26%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	124/481 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840