Protein Alignment lig and Ubap2l

DIOPT Version :10

• Sequence 1: NP_001260795.1
• Gene: lig / 35771
• FlyBaseID: FBgn0020279
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_001159455.1
• Gene: Ubap2l / 74383
• MGIID: 1921633
• Length: 1112
• Species: Mus musculus
• Alignment Length: 1322
• Identity: 358/1322 - (27%)
• Similarity: 527/1322 - (39%)
• Gaps: 335/1322 - (25%)

  Fly    50 QDASKTDKPEKAQPKATTEQLRIAQITNSTTEDPQINEKVLLLLTMTQRSEEEVCCALNECDYDL 114
            |..::.....|.:|:||.||:|:||:. |...|....|||..|:.:|.::::|...||::|:.|:
Mouse    16 QPQNQNQTQHKQRPQATAEQIRLAQMI-SDHNDADFEEKVKQLIDITGKNQDECVIALHDCNGDV 79

  Fly   115 EAAANFLIEELPQGAFAKYEKKRKNKAANNTADGAAGDGDWADGNGNADRREKSRNRSSNRGGT- 178
            ..|.|.|:|..|.  ...:|...|.|..:...||...:.: .:|..|.||   .|:.|..|||.
Mouse    80 NRAINVLLEGNPD--THSWEMVGKKKGVSGQKDGGQTESN-EEGKENRDR---DRDYSRRRGGPP 138

  Fly   179 ---RGSSDSRGWRGRETRENERNQRESREPWSGQNAGQDRGDDRANDNYRGQRNGGGRSGPGGGG 240
               ||:|..|.:||   :||..:..:|..| ||:  |.|||           |.|.|| |.|..|
Mouse   139 RRGRGASRGREFRG---QENGLDGTKSGGP-SGR--GTDRG-----------RRGRGR-GRGSSG 185

  Fly   241 RGGGFVSRSGRGGGRMGGRTGGPRGDRGSGGPGGAYGSGRGGNANEDHHEVELWDNTI------- 298
            |.||..|..|.|       |..|............||:..|...|...| .|..|.|.
Mouse   186 RRGGRFSAQGMG-------TFNPADYAEPANTDDNYGNSSGNTWNNTGH-FEPDDGTRLDFIGVE 242

  Fly   299 -AQNAEKQQQA----HDDAW----GDWNNEEYEGSLKDSKVFTTSNLAT--QSAANVVSGTGASV 352
             :....|.:.|    |..||    .:|..|::...|.::|:||.||:::  ..|.||....|..:
Mouse   243 GSNYPRKFETAPGMIHPGAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRI 307

  Fly   353 TAVPAAAGTEISAPPGLEHQLVQQGSHLEES-----------SSSGPAAVTPPATLSGSATTPLL 406
            ........|    |..:|:    ..|:|:.|           |:|...|::.||  |||.    .
Mouse   308 DLAVLLGKT----PSSMEN----DSSNLDPSQAPSLAQPLVFSNSKQNAISQPA--SGST----F 358

  Fly   407 QYSAAVSNPPPQLQSQGTQSGAGTGASAAAGGGAGSTPSSFVSASPDTFSSAASAAATLVHQAQK 471
            .:.:.||           ..|.|.|....|.||: :|.|.|:    :.|.:|.:    |...|.:
Mouse   359 SHHSMVS-----------MLGKGFGDVGEAKGGS-TTGSQFL----EQFKTAQA----LAQLAAQ 403

  Fly   472 QQQLQQQTTPI--KPSATLSVEQSQYFNSLAS-----------QGVSPGS----VPVQSAPAGYA 519
            ..|....||..  ..|.|.|....||....|:           |..:|.|    |.:|..|
Mouse   404 HSQSGSTTTSSWDMGSTTQSPSLVQYDLKSANDSTVHSPFTKRQAFTPSSTMMEVFLQEKP---- 464

  Fly   520 QNPVAAYSQTSTSVGVSQYP--NTYANVFASGTAAGAGTAEQSQQQPQIRRARVKLPPPSKIPAS 582
              |..|.|..:.....|..|  :|.|...:.|::....::.|..|| ::::.:.|....|||||.
Mouse   465 --PAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQ-KLKQQKKKTSLTSKIPAL 526

  Fly   583 AVEMPGDNALNNIGYLDVQFGALDFGTDDGFEPLPEKVGSGFSIDGQQQQQQPDDYQSKSQQQQQ 647
            ||||||.   .:|..|::|||||.||:    ||:                  ..||:|
Mouse   527 AVEMPGS---ADISGLNLQFGALQFGS----EPV------------------LSDYES------- 559

  Fly   648 VTLAAGLQSSQISDALNAAGYTSRSTSQQQQGVSSAVNATIDQLTKSDPYGQTGGSGNAYQNAYQ 712
             |......|||...:|    |||.::..     ||.|:                 |..:.::.||
Mouse   560 -TPTTSASSSQAPSSL----YTSTASES-----SSTVS-----------------SNQSQESGYQ 597

  Fly   713 SSGASKTASGFPTTAPGGYSSSTYANVQSSVANSYQQQGYGSYQPSSYQQQAGSGAQSGTGAVSG 777
            |               |...|:||.:..::....|:|:   |.|...|.....|..|...
Mouse   598 S---------------GPIQSTTYTSQNNAQGPLYEQR---STQTRRYPSSISSSPQKDL----- 639

  Fly   778 GGGTATQNIPVGGSSSQNSTSVSTSSGVSSNSGSTGNGGVVSGQTGANQAAVSNNNSVSGSSSVS 842
               |..:|    |.||..:|.:.|:..|   .|:||:  .|..::.:..:..|.|.:|..:|.::
Mouse   640 ---TQAKN----GFSSVQATQLQTTQSV---EGATGS--AVKSESPSTSSIPSLNETVPAASLLT 692

  Fly   843 NVTAGVASGNVAGVGGGVSQSGVSSGVGVPG------GSASSVGVNVNNNSSSASSVGAATVAQT 901
              ||...|.         |.||:|....:|.      .||.|...|..::|:|:.....:|:..|
Mouse   693 --TANQHSS---------SLSGLSHTEEIPNTTTTQHSSALSTQQNTLSSSTSSGRTSTSTLLHT 746

  Fly   902 ATGTTAAVLASLTNKNTSSSNSSGSGGSAATTTGNASGQGAGASTGGVGSSSGAGGAGSGGGSGS 966
            :..:.|.:.:|.:..:|:||..|......:.::...||...|.|.|  .:|:......|...:.|
Mouse   747 SVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLG--SNSTVTASTRSSVATTS 809

  Fly   967 GLVPTNIQ------MVSQYIQT-GLPY-YQQPVYSYEELQMMQQRVPHVQGYYDLNYP-PASLGA 1022
            |..|.|:.      :.:.||.. ||.: |...||.|::|||:|.|.|  ..||.:.:| |.:...
Mouse   810 GKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFP--LDYYSIPFPTPTTPLT 872

  Fly  1023 GRD-NLGSVTYSAMNDGRFARTDNNSSPVGNVSSTMSQQAGSSA----------PMLNVPYAY-- 1074
            ||| :|.|..||. :..:|.|.| .|||....:....||..:..          |.|...|:|
Mouse   873 GRDGSLASNPYSG-DLTKFGRGD-ASSPAPATTLAQPQQNQTQTHHTTQQTFLNPALPPGYSYTS 935

  Fly  1075 --FYGG-NVMPGSFQYGTPAIYPQIPAAN---------TASGQQFPKPSYSAGYGSTSYDTLSQT 1127
              :|.| ..:|.:|||| ||::|..|.::         .||...|.:||   ||||..|:|
Mouse   936 LPYYTGVPGLPSTFQYG-PAVFPVAPTSSKQHGVNVSVNASATPFQQPS---GYGSHGYNT---- 992

  Fly  1128 TQDYSKGGYSSSVNQQSKTQTVSNQSQAGTG-SDLTSSMYGKGHVALNKVNSYEKQSFHSGTP-P 1190
                   |.|         .|.||     || .|::.|:|.|..      .|:|||.|||||| .
Mouse   993 -------GVS---------VTSSN-----TGVPDISGSVYSKTQ------QSFEKQGFHSGTPAA 1030

  Fly  1191 PFNMPNTQTAGG-----TSAQPYGMYLPMP--------AAGHHNMIHQPIHQDSNS-AGQRQQST 1241
            .||:|:...:||     |:|    .|.|.|        ...|..::|..:.||..: :|||.|::
Mouse  1031 SFNLPSALGSGGPINPATAA----AYPPAPFMHILTPHQQPHSQILHHHLQQDGQTGSGQRSQTS 1091

  Fly  1242 S--QSKSAGKQGYSPSYWAGQN 1261
            |  |.....|..|:...| |.|
Mouse  1092 SIPQKPQTNKSAYNSYSW-GAN 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lig	NP_001260795.1	PRK12678	16..>229	CDD:237171	57/182 (31%)
		UBA_UBP2_like	85..122	CDD:270463	12/36 (33%)
		DUF3697	575..607	CDD:372135	18/31 (58%)
Ubap2l	NP_001159455.1	DUF3697	521..548	CDD:372135	18/29 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..681		41/194 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..819		32/135 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	890..926		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1065..1112		14/47 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		4/16 (25%)
		UBA_UBP2_like	50..87	CDD:270463	12/36 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..229		50/168 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..518		11/52 (21%)