DRSC/TRiP Functional Genomics Resources

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Protein Alignment lig and UBAP2

DIOPT Version :10

Sequence 1:NP_001260795.1 Gene:lig / 35771 FlyBaseID:FBgn0020279 Length:1417 Species:Drosophila melanogaster
Sequence 2:NP_060919.4 Gene:UBAP2 / 55833 HGNCID:14185 Length:1119 Species:Homo sapiens


Alignment Length:1340 Identity:370/1340 - (27%)
Similarity:542/1340 - (40%) Gaps:353/1340 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 HAAAAGKKGGQDASKTDKPEKAQPKATTEQLRIAQITNSTTEDPQINEKVLLLLTMTQRSEEEVC 104
            |...|.:|....|:::.:|:|...:||.||:|:||:. ....|.....||..|:.:|.::::|..
Human     9 HCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQVI-FDKNDSDFEAKVKQLMEVTGKNQDECI 72

  Fly   105 CALNECDYDLEAAANFLIEELPQGAFAKYEK---KRKNKAANNTADGAAGDGDWADGNGNADRRE 166
            .||::|:.|:..|.|.|:|  .......:|.   |:||.|..|:.              |.:.||
Human    73 VALHDCNGDVNKAINILLE--GNSDTTSWETVGCKKKNFAKENSE--------------NKENRE 121

  Fly   167 KSRNRSSNRGGTRGSSDSRGWRGRETRENERNQRESREPWSGQNAGQDRGD-DRANDNYRGQRNG 230
            |...:.|:||  ||:::.:|..|...||           :.|:..|.|... |:.:|  ||:|  
Human   122 KKSEKESSRG--RGNNNRKGRGGNRGRE-----------FRGEENGIDCNQVDKPSD--RGKR-- 169

  Fly   231 GGRSGPGGGGRGGGFVSRSGRGGGR-----MGGRTGGPRGDRGSGGPGG----AYGSGRGGNANE 286
                     .||.||....|||.||     ||........|..|....|    .:.:.:.| |:|
Human   170 ---------ARGRGFGRGRGRGAGRFSTQGMGTFNPADYSDSTSTDVCGTKLVVWEAAQNG-ADE 224

  Fly   287 DHHEVELWDNT--IAQN-AEKQQQAHDDAW----GDWNNEEYEGSLKDSKVFTTSNLATQSAANV 344
            .   .||..||  |||: :.|.......||    .:|..|::...|.::||||.|:...::  ::
Human   225 G---TELASNTHNIAQDLSNKSSYGLKGAWKNSVEEWTTEDWTEDLSETKVFTASSAPAEN--HI 284

  Fly   345 VSGTGASVTA-----VP-----AAAGTEISAPPGLEHQLVQQGSHLEESSSSGPAAVTPPATLSG 399
            :.|....:.|     ||     .|...|.|...|....||...|......:.|          :|
Human   285 LPGQSIDLVALLQKPVPHSQASEANSFETSQQQGFGQALVFTNSQHNNQMAPG----------TG 339

  Fly   400 SATTPLLQYSAAVSNPPPQLQSQGTQSGAGTGA----------------SAAAGGGAGSTPSSFV 448
            |:|        ||::..||..|....||.|..|                .|.:.|...:|||:..
Human   340 SST--------AVNSCSPQSLSSVLGSGFGELAPPKMANITSSQILDQLKAPSLGQFTTTPSTQQ 396

  Fly   449 SAS--PDTFSS-----AASAAATLVHQAQKQQQLQQQTTPIKPSATLS-VEQSQYFNSLASQGVS 505
            :::  |.|.:|     ..|.::.|.|...|.|.        :||..|| :.|.|...|.|.....
Human   397 NSTSHPTTTTSWDLKPPTSQSSVLSHLDFKSQP--------EPSPVLSQLSQRQQHQSQAVTVPP 453

  Fly   506 PGSVPVQSAPAGYAQNPVAAYSQTSTSVGVSQYPNTYANVFASGTAAGAGTAEQSQQQPQIRRAR 570
            ||   ::|.|:.............||...:.|.|:|        |......:....|...|:.|:
Human   454 PG---LESFPSQAKLRESTPGDSPSTVNKLLQLPST--------TIENISVSVHQPQPKHIKLAK 507

  Fly   571 VKLPPPSKIPASAVEMPGDNALNNIGYLDVQFGALDFGTDDGFEPLPEKVGSGFSIDGQQQQQQP 635
            .::||.||||||||||||.   .::..|:||||||:||:    ||...:.||..|          
Human   508 RRIPPASKIPASAVEMPGS---ADVTGLNVQFGALEFGS----EPSLSEFGSAPS---------- 555

  Fly   636 DDYQSKSQQQQQVTLAAGLQSSQISDALNAAGYTSRSTSQQQQGVSSAVNATIDQLTKSDPYGQT 700
                  |:...|:.::  |.|..:|:.||    ||.|       ::|||                
Human   556 ------SENSNQIPIS--LYSKSLSEPLN----TSLS-------MTSAV---------------- 585

  Fly   701 GGSGNAYQNA-YQSS---GASKTASGFPTTAPGGYSSSTYANVQSSVANSYQQQGYGSYQPSSYQ 761
                   ||: |.:|   ..|.|:|...:.:|...||| |.  ||||.|..           .||
Human   586 -------QNSTYTTSVITSCSLTSSSLNSASPVAMSSS-YD--QSSVHNRI-----------PYQ 629

  Fly   762 QQAGSGAQSGTGAVSGGGGTATQNIPVGGSSSQNSTSVSTSSGVSSNSGSTGNGGVVSGQTGANQ 826
            ... |.::|..|.:..|.|        ||.|.|...:..|                    ||...
Human   630 SPV-SSSESAPGTIMNGHG--------GGRSQQTLDTPKT--------------------TGPPS 665

  Fly   827 AAVSNNNSVSGSS------SVSNVTAGVASGNVAGVGGGVS--QSGVSSGVGVPGGSASSVGVNV 883
            |..|.::..|.:|      |.|..|..:.|..::.:...:|  ||.:|:...: ..|.|....:|
Human   666 ALPSVSSLPSTTSCTALLPSTSQHTGDLTSSPLSQLSSSLSSHQSSLSAHAAL-SSSTSHTHASV 729

  Fly   884 NNNSSSASSVGAATVAQTATGTTAAVLASLTNKNTSSSNSSGSGGSAATTTGNASGQGAGASTGG 948
            .:.||..||         ||.:|||.       :.|||.|||:..|::..|.|:      ...||
Human   730 ESASSHQSS---------ATFSTAAT-------SVSSSASSGASLSSSMNTANS------LCLGG 772

  Fly   949 VGSSSGAGGAGSGGGSGSGLVPTNIQ------MVSQYIQTG----LPYYQQPVYSYEELQMMQQR 1003
            ..:|:.:..:.:.....||..|.|:.      :.:||: .|    ||.|  |:|.|:||||:|.|
Human   773 TPASASSSSSRAAPLVTSGKAPPNLPQGVPPLLHNQYL-VGPGGLLPAY--PIYGYDELQMLQSR 834

  Fly  1004 VPHVQGYYDLNYPPASLGAGRDNL-------GSVTYSAMNDGRFARTDNNSSPVGNVSSTMSQQA 1061
            :|  ..||.:.:...:..|.||..       |.||       :|.|.| ::||....:....||:
Human   835 LP--VDYYGIPFAAPTALASRDGSLANNPYPGDVT-------KFGRGD-SASPAPATTPAQPQQS 889

  Fly  1062 GSSA------PMLN--VPYAYFYGG----NVMPGSFQYGTPAIYPQIPAANTASGQQFPKPSY-- 1112
            .|..      |.:|  :|..|.|.|    ..||.:||||.....|...|.........|.|.:  
Human   890 QSQTHHTAQQPFVNPALPPGYSYTGLPYYTGMPSAFQYGPTMFVPPASAKQHGVNLSTPTPPFQQ 954

  Fly  1113 SAGYG----STSYDTLSQTTQ--DYSKGGYSSSVNQQSKT------QTVSNQSQAGTGSDLTSSM 1165
            ::|||    ||.||.|:|.|.  |||||||:.|....:|:      :.||..|......|:|.|:
Human   955 ASGYGQHGYSTGYDDLTQGTAAGDYSKGGYAGSSQAPNKSAGSGPGKGVSVSSSTTGLPDMTGSV 1019

  Fly  1166 YGKGHVALNKVNSYEKQSFHSGTPPPFNMPN---------TQTAGGTSAQPYGMYLPMPAAGHHN 1221
            |       ||..:::||.||:||||||::|:         :..|.|.:..|:...||.....|..
Human  1020 Y-------NKTQTFDKQGFHAGTPPPFSLPSVLGSTGPLASGAAPGYAPPPFLHILPAHQQPHSQ 1077

  Fly  1222 MIHQPIHQDSNS-AGQRQQSTS-QSKS-AGKQGYSPS-YW 1257
            ::|..:.||:.| :|||.|.:| |.|| |.|..|..| ||
Human  1078 LLHHHLPQDAQSGSGQRSQPSSLQPKSQASKPAYGNSPYW 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ligNP_001260795.1 PRK12678 16..>229 CDD:237171 53/192 (28%)
UBA_UBP2_like 85..122 CDD:270463 11/36 (31%)
DUF3697 575..607 CDD:372135 20/31 (65%)
UBAP2NP_060919.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 4/16 (25%)
UBA_UBP2_like 53..90 CDD:270463 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..202 34/131 (26%)
Atrophin-1 300..>681 CDD:460830 132/519 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..476 24/101 (24%)
DUF3697 512..541 CDD:372135 20/31 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 622..736 33/154 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 853..905 15/59 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 937..966 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 982..1020 11/37 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1082..1119 17/36 (47%)

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