DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and ztf-16

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001024851.1	Gene:	ztf-16 / 180756	WormBaseID:	WBGene00019960	Length:	480	Species:	Caenorhabditis elegans

Alignment Length:	695	Identity:	146/695 - (21%)
Similarity:	223/695 - (32%)	Gaps:	271/695 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HHNAMALRSLKDAASSAS-------ESELQEPRS-----PTPTPTNLSTGPHSPPMTFRCERCDS 92
            |.|..:..|..:.::|.:       :|....|||     |||:|.:.....|...:|........
Worm    27 HENEHSRSSSGEMSNSQTIEWGDGIQSSTPSPRSTPPSDPTPSPDSDEHLEHHISITEITNTLIK 91

  Fly    93 FETSSRASLLLHV------VQCLAGQAAAAAAAAAASARLKSEDLQEPENMSLGHMEG-GKGDGQ 150
            .|..::....:||      ..|:             |..:||            |:|. .:..||
Worm    92 KEPGTKGQKTVHVCPHCNFTTCM-------------SQHMKS------------HLEAHERHQGQ 131

  Fly   151 TGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQ 215
                                         :::||:|.|:||..|||.||:|||:||||||||.|:
Worm   132 -----------------------------MYQCDICKMQFSQKANMHRHRMRHSGVKPYECRFCK 167

  Fly   216 KRFFRKDHLAEHFTTHTKT-LPYHCPI--CNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLCSYRA 277
            |||||||.:.||..||.|| ..:.||:  ||..|.:..|:|||.:..|........:|..|:...
Worm   168 KRFFRKDQMQEHSMTHIKTGFGFDCPVSQCNMQFSQHNALRAHLEETHTISSTNPASCKRCNLMF 232

  Fly   278 GSMKSLRIHFFNRHGIDLDNPGPGGTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQ 342
            .:.:.|.:||..||.....:|....|..........|           :|...:.:.:..|.|:.
Worm   233 ANSRRLLLHFQTRHDDSESSPKKENTPKRKKLSNGNA-----------LPMDPANMSITEQLQRM 286

  Fly   343 QQQQVAPPASDSGESMRSLENATPPMHFLTPHVEISTLGESGNTELFNLICVWRESALQGNNNNN 407
            .:.:.:||.:|:.::..|.|....|..|...:.:|.            |:|:
Worm   287 VKSEFSPPNTDTSDNSTSSEFDKIPPSFPMANPDIL------------LMCL------------- 326

  Fly   408 NNNNCATNNNNNINGASNNCNSISNGNAESNGDKVKDRALIMQSPVELPMDCNTKATPITSSTTA 472
                   |..|..||...|                          :..|| .|....|:.:.
Worm   327 -------NQMNQFNGFGEN--------------------------IPRPM-LNIPNIPLPAL--- 354

  Fly   473 SSLSGGLKSHHQHPHHHHHHHHHHENHITPSISLIPIKQEPMSEDMDKKDLMNGSDPSSDTEQAS 537
                                      |..|:::.| :||                    |..|..
Worm   355 --------------------------HNIPAVAAI-VKQ--------------------DQVQLW 372

  Fly   538 NNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNGS 602
            :...|||        :.||.                        .:|.|.:::.....:|||...
Worm   373 SEQTSSS--------VSVSA------------------------PSPSEQSHSPPANESSLSLTE 405

  Fly   603 GRGSPGVNGGSGGGGGGGPPTPATPSATNGASSTPICNGTITSTGQDGDLLINRKLILTCHFCGI 667
            ...|               |||......|                           :..|| ||:
Worm   406 KEKS---------------PTPEKEDEEN---------------------------VECCH-CGM 427

  Fly   668 EFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSKSH 712
            .|.|.|:|.|||..|.:.:|::|.:||.|....|.|.:|::...|
Worm   428 MFYDNTMYLLHKSLHSDGDPFKCALCGTQCGEKYMFTTHVIFADH 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	12/19 (63%)
		zf-H2C2_2	195..218	CDD:290200	17/22 (77%)
		C2H2 Zn finger	211..231	CDD:275368	12/19 (63%)
		C2H2 Zn finger	239..255	CDD:275368	7/17 (41%)
		C2H2 Zn finger	662..689	CDD:275371	13/26 (50%)
		C2H2 Zn finger	690..712	CDD:275371	7/21 (33%)
ztf-16	NP_001024851.1	C2H2 Zn finger	105..125	CDD:275368	6/44 (14%)
		C2H2 Zn finger	135..155	CDD:275368	12/19 (63%)
		C2H2 Zn finger	163..183	CDD:275368	12/19 (63%)
		C2H2 Zn finger	225..246	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159857
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I2673
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591567at33208
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	1	1.000	-	-		otm14416
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24404
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3390
SonicParanoid	1	1.000	-	-		X13813
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.030