Protein Alignment Hey and HES4

DIOPT Version :10

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_001135939.1
• Gene: HES4 / 57801
• HGNCID: 24149
• Length: 247
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 86/276 - (31%)
• Similarity: 118/276 - (42%)
• Gaps: 57/276 - (20%)

  Fly    18 AAGPGVVMPGATATTPQSHWVPPPQSHHSAHSNHSHGHSQGHSHGIGSLKRTLSESDCDDLYSEE 82
            :|.|   |.||.|:..::     |....||..:...|...|.....|               ..|
Human    10 SASP---MAGAPASASRT-----PDKPRSAAEHRKVGSRPGVRGATG---------------GRE 51

  Fly    83 SSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGS--AKLEKAEIL 145
            ....|..|....|         :.|:||:||.|||.||.:||.|:..|..|:.|  :|||||:||
Human    52 GRGTQPVPDPQSS---------KPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADIL 107

  Fly   146 QLTVEHLKSLQS-KTLDSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSH 209
            ::||.||:||:. :...:||.||  ..:..:..||.||.|||.|:|...||  :...:|.||:.|
Human   108 EMTVRHLRSLRRVQVTAALSADP--AVLGKYRAGFHECLAEVNRFLAGCEG--VPADVRSRLLGH 168

  Fly   210 LQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNCAA---------APYQSYAAPANPGAYVSSY 265
            |...::|...|.:    |...|||||:.:. .|...|         .|:...|.|..||.    .
Human   169 LAACLRQLGPSRR----PASLSPAAPAEAP-APEVYAGRPLLPSLGGPFPLLAPPLLPGL----T 224

  Fly   266 PTLSASPSQQAQQLGG 281
            ..|.|:|....|..||
Human   225 RALPAAPRAGPQGPGG 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	bHLH_SF	95..163	CDD:469605	30/70 (43%)
		ORANGE	172..218	CDD:128787	17/45 (38%)
HES4	NP_001135939.1	bHLH-O_HES1_4	62..121	CDD:381465	30/67 (45%)
		Hairy_orange	135..174	CDD:462193	16/40 (40%)