Protein Alignment Hey and HES2

DIOPT Version :10

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 171
• Identity: 56/171 - (32%)
• Similarity: 91/171 - (53%)
• Gaps: 24/171 - (14%)

  Fly   101 RKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGS--AKLEKAEILQLTVEHLKSLQSKTLDSL 163
            ||..:.::||:||.|||.||::||.|:.....::.|  :|||||::|::||..|:.|.:.:..:.
Human    14 RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTA 78

  Fly   164 SYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDP-LRLRLMSHLQYFVQQRELSA-----K 222
            :..|    .|.:..|:..|.|.:||.|....   :.:| :..||:.||    .:|..||     :
Human    79 APLP----CDSYREGYSACVARLARVLPACR---VLEPAVSARLLEHL----WRRAASATLDGGR 132

  Fly   223 SCASPGGWSPA-APSSSGYQPNCAAAPYQS-YAAPANPGAY 261
            :..|.|..:|| ||:|:   |..|:||..| .:.|..||.:
Human   133 AGDSSGPSAPAPAPASA---PEPASAPVPSPPSPPCGPGLW 170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	bHLH_SF	95..163	CDD:469605	25/63 (40%)
		ORANGE	172..218	CDD:128787	12/46 (26%)
HES2	NP_061962.2	bHLH-O_HES2	10..74	CDD:381469	25/59 (42%)
		ORANGE	84..127	CDD:128787	14/49 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		15/46 (33%)
		WRPW motif	170..173		0/1 (0%)