Protein Alignment Hey and hes4

DIOPT Version :10

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_988870.1
• Gene: hes4 / 394465
• XenbaseID: XB-GENE-487830
• Length: 281
• Species: Xenopus tropicalis
• Alignment Length: 342
• Identity: 95/342 - (27%)
• Similarity: 134/342 - (39%)
• Gaps: 95/342 - (27%)

  Fly    89 SPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGS--AKLEKAEILQLTVEH 151
            :|.:|.|.. ..||..:.::||:||.|||.||.:||.|:..|.:|..|  :|||||:||::||:|
 Frog    24 TPDKPKSAS-EHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKH 87

  Fly   152 LKSLQSKTLD-SLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQ 215
            |::||...:. :|:.||.  .:..:..||.||..||.|:|.|.||::.:  :|.||:.||...:.
 Frog    88 LRNLQRVQMTAALTADPS--VLGKYRAGFNECMNEVTRFLSTCEGVNTE--VRTRLLGHLSSCLG 148

  Fly   216 QRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQLG 280
            |  :.|.:...|       |||.  ||.....| .|..||......|:....:|....|     |
 Frog   149 Q--IVAMNYQQP-------PSSQ--QPLHVQLP-SSTPAPVPMPCKVNPAEAISPKVFQ-----G 196

  Fly   281 GRTSVSRTSGSAVTESLPSHDLHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQ 345
            |...|..|.|                                           |.....|.|.
 Frog   197 GFQLVPATDG-------------------------------------------QFAFLIPNPA-- 216

  Fly   346 QHYTHDHSAVHSEQQVPTYIELTNSNRPAAIGSDSLSYSAAPQYPVSGLPGQDYNNSSVLQYATP 410
              ||.....|     :|.|   .|:|..:..|..|       |.||.||....:....:.|..:|
 Frog   217 --YTTSPGPV-----IPLY---ANTNVTSPGGPQS-------QSPVQGLTTFGHKMPHMAQAVSP 264

  Fly   411 NGAKP--------YRPW 419
            .|...        :|||
 Frog   265 LGGSTGADSAESVWRPW 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	bHLH_SF	95..163	CDD:469605	31/70 (44%)
		ORANGE	172..218	CDD:128787	17/45 (38%)
hes4	NP_988870.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		5/20 (25%)
		bHLH-O_HES1_4	33..95	CDD:381465	30/61 (49%)
		Hairy_orange	109..147	CDD:462193	16/39 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..281		3/18 (17%)
		WRPW motif. /evidence=ECO:0000255	278..281		1/2 (50%)