Protein Alignment Hey and HES5

DIOPT Version :10

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: XP_005244808.1
• Gene: HES5 / 388585
• HGNCID: 19764
• Length: 198
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 54/212 - (25%)
• Similarity: 87/212 - (41%)
• Gaps: 61/212 - (28%)

  Fly    86 EQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEK-QGSAKLEKAEILQLTV 149
            |.:||.|       ..:.|:.|:||.||||||||:.:||.|:...:.: |.::|||||:||::.|
Human     9 ELLSPKE-------KNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAV 66

  Fly   150 EHLKSLQSKTLDS-----------------------------LSYDPQRVAMDYHIIGFRECAAE 185
            .:||..:.:...:                             .:..|:.:..||. .|:..|..|
Human    67 SYLKHSKGERARAPRAPSSHRAPAPPRPAARSPPPRLPAAFVAAAGPKSLHQDYS-EGYSWCLQE 130

  Fly   186 VARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNC-AAAPY 249
            ..::|......|.|    ::|:.|.|.                  .||||::...:|.. .|||.
Human   131 AVQFLTLHAASDTQ----MKLLYHFQR------------------PPAAPAAPAKEPKAPGAAPP 173

  Fly   250 QSYAAPANPGAYVSSYP 266
            .:.:|.|...|..:..|
Human   174 PALSAKATAAAAAAHQP 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	bHLH_SF	95..163	CDD:469605	26/97 (27%)
		ORANGE	172..218	CDD:128787	11/45 (24%)
HES5	XP_005244808.1	bHLH-O_HES5	18..74	CDD:381467	26/55 (47%)
		Hairy_orange	118..153	CDD:470640	10/39 (26%)