Protein Alignment Nup44A and SEH1L

DIOPT Version :10

• Sequence 1: NP_610343.1
• Gene: Nup44A / 35762
• FlyBaseID: FBgn0033247
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: XP_011524044.1
• Gene: SEH1L / 81929
• HGNCID: 30379
• Length: 441
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 194/366 - (53%)
• Similarity: 254/366 - (69%)
• Gaps: 36/366 - (9%)

  Fly     1 MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSW 65
            ||....|.|||||:||||.||::|||||||||||:||:||:...|.|:.|:|||.||||:|||:|
Human     1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65

  Fly    66 AHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTR---RWVRRTTLVDSRTSVTDVEFAPKYL 127
            ||||||||:|:|||||||:||||::||    :|...|   .||:||||||||||||||:||||::
Human    66 AHPEFGQVLASCSFDRTAAVWEEIVGE----SNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126

  Fly   128 GLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWN-------------------- 172
            ||:|||.|||||:|||||||:||||||.:|||||.||..||:|||
Human   127 GLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSRISKLIEKMNRAHLYNFH 191

  Fly   173 -TSTYMVTQLLAAGSDEAA-TPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFH 235
             .|:...:.::|.|||::: ....||.:|.|:||:||..|.:|:..:||||.|:|||||.||:||
Human   192 IPSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFH 256

  Fly   236 MLAVASKDLYIVNLRGV----TDATDISKLDIQTI-KFSEHNCPVWRVCWNMLATMLISTGDDGC 295
            :||:|:||:.|..|:.|    |.:...:|.:|..: :|..||..||||.||:..|:|.|:|||||
Human   257 ILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGC 321

  Fly   296 VRLWRMNYNRQWRCAAVLKAEGS--GPTYEPAPPTPTLATT 334
            ||||:.||...|:|..:||..||  ..:.:.....|:|.:|
Human   322 VRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGST 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	<8..302	CDD:441893	180/323 (56%)
		WD40 repeat	16..55	CDD:293791	25/38 (66%)
		WD40 repeat	60..98	CDD:293791	26/37 (70%)
		WD40 repeat	118..159	CDD:293791	31/40 (78%)
		WD40 repeat	166..212	CDD:293791	19/67 (28%)
		WD40 repeat	221..267	CDD:293791	22/50 (44%)
		WD40 repeat	275..299	CDD:293791	16/23 (70%)
SEH1L	XP_011524044.1	WD40	<11..348	CDD:441893	186/340 (55%)
		WD40 repeat	15..55	CDD:293791	26/39 (67%)
		WD40 repeat	61..111	CDD:293791	34/53 (64%)
		WD40 repeat	116..149	CDD:293791	25/32 (78%)
		WD40 repeat	166..232	CDD:293791	18/65 (28%)
		WD40 repeat	242..287	CDD:293791	21/44 (48%)
		WD40 repeat	301..340	CDD:293791	22/38 (58%)