DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and SEH1L

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_011524044.1	Gene:	SEH1L / 81929	HGNCID:	30379	Length:	441	Species:	Homo sapiens

Alignment Length:	366	Identity:	194/366 - (53%)
Similarity:	254/366 - (69%)	Gaps:	36/366 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSW 65
            ||....|.|||||:||||.||::|||||||||||:||:||:...|.|:.|:|||.||||:|||:|
Human     1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65

  Fly    66 AHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTR---RWVRRTTLVDSRTSVTDVEFAPKYL 127
            ||||||||:|:|||||||:||||::||    :|...|   .||:||||||||||||||:||||::
Human    66 AHPEFGQVLASCSFDRTAAVWEEIVGE----SNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126

  Fly   128 GLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWN-------------------- 172
            ||:|||.|||||:|||||||:||||||.:|||||.||..||:|||
Human   127 GLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSRISKLIEKMNRAHLYNFH 191

  Fly   173 -TSTYMVTQLLAAGSDEAA-TPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFH 235
             .|:...:.::|.|||::: ....||.:|.|:||:||..|.:|:..:||||.|:|||||.||:||
Human   192 IPSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFH 256

  Fly   236 MLAVASKDLYIVNLRGV----TDATDISKLDIQTI-KFSEHNCPVWRVCWNMLATMLISTGDDGC 295
            :||:|:||:.|..|:.|    |.:...:|.:|..: :|..||..||||.||:..|:|.|:|||||
Human   257 ILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGC 321

  Fly   296 VRLWRMNYNRQWRCAAVLKAEGS--GPTYEPAPPTPTLATT 334
            ||||:.||...|:|..:||..||  ..:.:.....|:|.:|
Human   322 VRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGST 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	177/318 (56%)
		WD40 repeat	16..55	CDD:293791	25/38 (66%)
		WD40 repeat	60..98	CDD:293791	26/37 (70%)
		WD40 repeat	118..159	CDD:293791	31/40 (78%)
		WD40 repeat	166..212	CDD:293791	19/67 (28%)
		WD40 repeat	221..267	CDD:293791	22/50 (44%)
		WD40 repeat	275..299	CDD:293791	16/23 (70%)
SEH1L	XP_011524044.1	WD40	11..328	CDD:225201	178/320 (56%)
		WD40	11..326	CDD:295369	177/318 (56%)
		WD40 repeat	15..55	CDD:293791	26/39 (67%)
		WD40 repeat	61..111	CDD:293791	34/53 (64%)
		WD40 repeat	116..149	CDD:293791	25/32 (78%)
		WD40 repeat	166..232	CDD:293791	18/65 (28%)
		WD40 repeat	242..287	CDD:293791	21/44 (48%)
		WD40 repeat	301..340	CDD:293791	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148076
Domainoid	1	1.000	272	1.000	Domainoid score	I1817
eggNOG	1	0.900	-	-		E1_KOG2445
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68701
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1938
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55323
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	1	1.000	-	-		FOG0004075
OrthoInspector	1	1.000	-	-		oto90528
orthoMCL	1	0.900	-	-		OOG6_103638
Panther	1	1.100	-	-	LDO	PTHR11024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1316
SonicParanoid	1	1.000	-	-		X3915
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800