Protein Alignment Nup44A and SEC13

DIOPT Version :10

• Sequence 1: NP_610343.1
• Gene: Nup44A / 35762
• FlyBaseID: FBgn0033247
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001129498.1
• Gene: SEC13 / 6396
• HGNCID: 10697
• Length: 368
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 105/339 - (30%)
• Similarity: 160/339 - (47%)
• Gaps: 58/339 - (17%)

  Fly     4 VEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSWAHP 68
            :..:...|:|:|||...||||.|:||||||::|||:|....|: .:.:..:.|.|.:|:|:||||
Human    51 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ-ILIADLRGHEGPVWQVAWAHP 114

  Fly    69 EFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTRRWVRRTTLVDSRTSVTDVEFAPKYLGLLLAT 133
            .:|.::|:||:||...:|.|..|           .|.:........:||..|.:||...||:||.
Human   115 MYGNILASCSYDRKVIIWREENG-----------TWEKSHEHAGHDSSVNSVCWAPHDYGLILAC 168

  Fly   134 ASADGIIRI--YEAPDIMNLSQWPVQHEISNKLPLSC--LSWNTSTYMVTQLLAAGS--DEAATP 192
            .|:||.|.:  |...     .||.|: :|:|...:.|  :||       ...:..||  |.   |
Human   169 GSSDGAISLLTYTGE-----GQWEVK-KINNAHTIGCNAVSW-------APAVVPGSLIDH---P 217

  Fly   193 TG------KVFLFAYSENSRKCVKID---------TVNDITDPVTDVAFAPNAGRTFHMLAVASK 242
            :|      |.|.....:|..|..|.:         .:...:|.|.|||:||:.|.....:|..|:
Human   218 SGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 282

  Fly   243 D--LYIVNLRGVTDATDISKLDIQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNR 305
            |  ::|......:..|...||      ..:.|..||.|.|::.|.:|..:|.|..|.||:.:.:.
Human   283 DGRVFIWTCDDASSNTWSPKL------LHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG 341

  Fly   306 QWRCAA-VLKAEGS 318
            ||.|.: |.|.:||
Human   342 QWVCISDVNKGQGS 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	<8..302	CDD:441893	98/316 (31%)
		WD40 repeat	16..55	CDD:293791	18/38 (47%)
		WD40 repeat	60..98	CDD:293791	15/37 (41%)
		WD40 repeat	118..159	CDD:293791	15/42 (36%)
		WD40 repeat	166..212	CDD:293791	13/55 (24%)
		WD40 repeat	221..267	CDD:293791	14/47 (30%)
		WD40 repeat	275..299	CDD:293791	9/23 (39%)
SEC13	NP_001129498.1	WD40	<71..335	CDD:441893	88/297 (30%)
		WD40 repeat	107..147	CDD:293791	16/50 (32%)
		WD40 repeat	152..198	CDD:293791	18/51 (35%)
		WD40 repeat	206..255	CDD:293791	10/51 (20%)
		WD40 repeat	261..302	CDD:293791	12/40 (30%)
		WD40 repeat	311..337	CDD:293791	11/25 (44%)