DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and seh1l

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_012820038.1	Gene:	seh1l / 496570	XenbaseID:	XB-GENE-1015661	Length:	416	Species:	Xenopus tropicalis

Alignment Length:	329	Identity:	188/329 - (57%)
Similarity:	251/329 - (76%)	Gaps:	16/329 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSW 65
            ||....|.|||||:||||.||::|||||||||||:||:||:...|.|:.|:|||.||||:|||:|
Frog     1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSENGDWHCTASWKTHSGSVWRVTW 65

  Fly    66 AHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTR---RWVRRTTLVDSRTSVTDVEFAPKYL 127
            ||||||||:|:|||||||:||||::||    :|...|   .||:||||||||||||||:||||::
Frog    66 AHPEFGQVLASCSFDRTAAVWEEIVGE----SNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126

  Fly   128 GLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWNTSTYMV-TQLLAAGSDEAAT 191
            ||:|||.||||::|||||||:||||||.:|||||.||..||:|||.|:... :.::|.|||: ::
Frog   127 GLMLATCSADGVVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDD-SS 190

  Fly   192 PT--GKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYIVNL----R 250
            |.  |||.::.|:||:||..|.:|:..::|||.|:|||||.||:||:||||:||:.|..:    :
Frog   191 PNIMGKVQIYEYNENTRKYAKAETLMSVSDPVHDIAFAPNLGRSFHILAVATKDVRIFTMKPLRK 255

  Fly   251 GVTDATDISKLDIQTI-KFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQWRCAAVLK 314
            .::.:..::|.:|.|: :|..||..||||.||:..|:|.|:||||.||||:.||...|:|..|||
Frog   256 ELSSSGGVTKFEIHTVAQFDNHNSQVWRVSWNITGTVLASSGDDGTVRLWKANYMDNWKCIGVLK 320

  Fly   315 AEGS 318
            .:|:
Frog   321 GDGN 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	174/299 (58%)
		WD40 repeat	16..55	CDD:293791	25/38 (66%)
		WD40 repeat	60..98	CDD:293791	26/37 (70%)
		WD40 repeat	118..159	CDD:293791	30/40 (75%)
		WD40 repeat	166..212	CDD:293791	20/48 (42%)
		WD40 repeat	221..267	CDD:293791	21/50 (42%)
		WD40 repeat	275..299	CDD:293791	15/23 (65%)
seh1l	XP_012820038.1	WD40	11..306	CDD:392136	174/299 (58%)
		WD40 repeat	15..55	CDD:293791	26/39 (67%)
		WD40 repeat	61..111	CDD:293791	34/53 (64%)
		WD40 repeat	116..149	CDD:293791	24/32 (75%)
		WD40 repeat	166..212	CDD:293791	19/46 (41%)
		WD40 repeat	222..267	CDD:293791	19/44 (43%)
		WD40 repeat	281..320	CDD:293791	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1769
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68701
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1902
OMA	1	1.010	-	-		QHG55323
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	1	1.000	-	-		FOG0004075
OrthoInspector	1	1.000	-	-		otm48851
Panther	1	1.100	-	-	LDO	PTHR11024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1316
SonicParanoid	1	1.000	-	-		X3915
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110