DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup44A and sec13

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_988967.1	Gene:	sec13 / 394564	XenbaseID:	XB-GENE-944452	Length:	320	Species:	Xenopus tropicalis

Alignment Length:	350	Identity:	101/350 - (28%)
Similarity:	160/350 - (45%)	Gaps:	75/350 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSWAHP 68
            :..:...|:|:|||...||||.|:||||||::|||:|....|: .:.:..:.|.|.:|:|:||||
Frog     5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVKNGGQ-ILIADLRGHEGPVWQVAWAHP 68

  Fly    69 EFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTRRWVRRTTLVDSRTSVTDVEFAPKYLGLLLAT 133
            .:|.::|:||:||...:|:|..|           .|.:........:||..|.:||..|||:||.
Frog    69 MYGNILASCSYDRKVIIWKEENG-----------TWEKTYEYTGHDSSVNSVCWAPHDLGLVLAC 122

  Fly   134 ASADGIIRIY----EAPDIMNLSQWPVQHEISNKLPLSC--LSWNTSTY--------------MV 178
            .|:||.|.|.    :.|       |.|: :|||...:.|  :||..|..              .:
Frog   123 GSSDGAISILTYTGDGP-------WEVK-KISNAHTIGCNAVSWAPSVVPGSLVDQPSSQKPNYI 179

  Fly   179 TQLLAAGSDEAATPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKD 243
            .:.::.|.|...    |:    :.|...:..:...:...:|.|.|||:||:.|.....:|..|:|
Frog   180 KRFVSGGCDNLV----KI----WREEDGQWKEDQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQD 236

  Fly   244 LYIVNLRGVTDATDISKLDIQTIKFSEHNC-----------PVWRVCWNMLATMLISTGDDGCVR 297
                           .::.|.|...:..||           .||.|.|::.|.:|..:|.|..|.
Frog   237 ---------------GRVYIWTSDDAATNCWNPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 286

  Fly   298 LWRMNYNRQWRCAA-VLKAEGSGPT 321
            ||:.:.:.||.|.: |.|.:|:..|
Frog   287 LWKESVDGQWACISDVNKGQGAVST 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	93/319 (29%)
		WD40 repeat	16..55	CDD:293791	18/38 (47%)
		WD40 repeat	60..98	CDD:293791	15/37 (41%)
		WD40 repeat	118..159	CDD:293791	16/44 (36%)
		WD40 repeat	166..212	CDD:293791	8/61 (13%)
		WD40 repeat	221..267	CDD:293791	12/45 (27%)
		WD40 repeat	275..299	CDD:293791	9/23 (39%)
sec13	NP_988967.1	WD40	10..288	CDD:392136	92/320 (29%)
		WD40 repeat	61..101	CDD:293791	16/50 (32%)
		WD40 repeat	106..152	CDD:293791	20/53 (38%)
		WD40 repeat	160..208	CDD:293791	5/55 (9%)
		WD40 repeat	214..256	CDD:293791	14/56 (25%)
		WD40 repeat	264..290	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010