DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and seh1l

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_021323675.1	Gene:	seh1l / 334749	ZFINID:	ZDB-GENE-030131-6689	Length:	410	Species:	Danio rerio

Alignment Length:	362	Identity:	191/362 - (52%)
Similarity:	260/362 - (71%)	Gaps:	25/362 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSW 65
            ||..:.|.|||||:||||.:|::|||||||||||:||:||:...|:|:.|:|||.||||:|||:|
Zfish     1 MFVAKSIAADHKDLIHDVSYDFHGRRMATCSSDQSVKVWDKGDDGEWHCTASWKTHSGSVWRVTW 65

  Fly    66 AHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTR---RWVRRTTLVDSRTSVTDVEFAPKYL 127
            ||||||||:|:|||||||:||||::||    :|...|   .|::||||||||||||||:||||::
Zfish    66 AHPEFGQVLASCSFDRTAAVWEEIVGE----SNDKQRGQSHWIKRTTLVDSRTSVTDVKFAPKHM 126

  Fly   128 GLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWNTSTYMV-TQLLAAGSDEA-A 190
            ||:|.|.||||::|||||||:||||||.:|||||.||..||:|||.|:... ..::|.|.|:: .
Zfish   127 GLMLTTCSADGVVRIYEAPDVMNLSQWSLQHEISCKLACSCISWNPSSSRAHPPMIAVGGDDSNG 191

  Fly   191 TPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYIVNL----RG 251
            ..:|||.:..|:||:||..|.:|:..:||||.|:|||||.||:||:||:|:||:.|..|    |.
Zfish   192 AYSGKVQIHEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHVLAIATKDVRIFKLLPLRRE 256

  Fly   252 VTDATDISKLDIQTI-KFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQWRCAAVLKA 315
            ..:::..:|.::|.: :|..||..||||.||:.:|:|.|:|||||||||:.||...|:|..:|:.
Zfish   257 SANSSGPTKFEVQVMAQFDSHNSQVWRVSWNITSTLLASSGDDGCVRLWKANYMDNWKCTGILRG 321

  Fly   316 EGSGPTYEPAPPTPTLAT----------TASATAKFY 342
            :|| |....:.|:..|:.          ..:|||..|
Zfish   322 DGS-PVNGSSGPSAALSAVGVPGAAQMIVGAATAGRY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	171/298 (57%)
		WD40 repeat	16..55	CDD:293791	24/38 (63%)
		WD40 repeat	60..98	CDD:293791	26/37 (70%)
		WD40 repeat	118..159	CDD:293791	29/40 (73%)
		WD40 repeat	166..212	CDD:293791	18/47 (38%)
		WD40 repeat	221..267	CDD:293791	21/50 (42%)
		WD40 repeat	275..299	CDD:293791	16/23 (70%)
seh1l	XP_021323675.1	WD40	11..306	CDD:330360	171/298 (57%)
		WD40 repeat	15..55	CDD:293791	25/39 (64%)
		WD40 repeat	61..111	CDD:293791	33/53 (62%)
		WD40 repeat	116..149	CDD:293791	23/32 (72%)
		WD40 repeat	166..212	CDD:293791	17/45 (38%)
		WD40 repeat	222..275	CDD:293791	21/52 (40%)
		WD40 repeat	281..307	CDD:293791	18/25 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582004
Domainoid	1	1.000	266	1.000	Domainoid score	I1847
eggNOG	1	0.900	-	-		E1_KOG2445
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68701
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1919
OMA	1	1.010	-	-		QHG55323
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	1	1.000	-	-		FOG0004075
OrthoInspector	1	1.000	-	-		oto40464
orthoMCL	1	0.900	-	-		OOG6_103638
Panther	1	1.100	-	-	LDO	PTHR11024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1316
SonicParanoid	1	1.000	-	-		X3915
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800