DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8726 and MDM1

DIOPT Version :10

Sequence 1:NP_610341.2 Gene:CG8726 / 35758 FlyBaseID:FBgn0033244 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_013603.1 Gene:MDM1 / 854867 SGDID:S000004572 Length:1127 Species:Saccharomyces cerevisiae


Alignment Length:712 Identity:121/712 - (16%)
Similarity:223/712 - (31%) Gaps:277/712 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LPI---------DDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSLR 67
            |||         |..:|:..::|..:..:.:.:..:.|   ..||||           ::.|||.
Yeast   152 LPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAV---EFNKNY-----------KIHKSLS 202

  Fly    68 V------SGIELPLPRKRIFGNMRPEFIAERKQAL------QEYINAVLMNPILASSLPAKRFVD 120
            :      ..||..: ||.:.|.:...|..:...:|      .|.:...:::|::.      :|.|
Yeast   203 LKPNALQKEIEKSI-RKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIF------KFTD 260

  Fly   121 PESY-------SQSFHD--HAVQNAMLCL----------RNDTTWSLGGSMGAIGWRLR------ 160
            |:|:       ||::.:  |.|......|          .||......|...:....|.      
Yeast   261 PDSWNLRIVSLSQNYFEEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGK 325

  Fly   161 --KHY-----------------FKVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHSIDA 206
              :||                 :.:..|..:...|:.|.|...: ::.:...:.:...|..|...
Yeast   326 QFEHYLNQLDSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLK-YKKRLLLSLNLIESKLSFPG 389

  Fly   207 GTLDPGSEVVAEWLEYGPDKFIDE----KEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKF 267
            ..:|..|:.:|....| ||..:|.    ||:...:.|:                           
Yeast   390 SEIDTASKKLAREANY-PDLNMDNGIVLKEMASFLTSI--------------------------- 426

  Fly   268 HKHGTLKDVL-----------CMAANPK---NTFL------SKYGNP----------KGRTALSM 302
                ||||::           .:.:.|:   :|||      ..:.||          .|.:.:|.
Yeast   427 ----TLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGIST 487

  Fly   303 KQVATYG------------KQILEAL---IFLHSKGYAYGH-------LHSGNIVIVDDCVKLLD 345
            .|:....            |.:.|.|   |.|....:...:       .....:::..:.:|.||
Yeast   488 MQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLD 552

  Fly   346 IENFLLGVPAFYR-PFFMQH-SKIHAIETIDVYCFGHVLFEM-AMGYPLQESVVRQ--------- 398
             :.||   |.|.: |.|::. |..|.|.| |:|  .|.|..: .:..|.|..:::.         
Yeast   553 -DRFL---PLFKKTPSFLKMLSTSHIIST-DIY--AHFLSRIGGVNNPEQNKIIKDNVKTDFMNP 610

  Fly   399 --------ITECPEALKCLLESILSKEACK------AGLPTLEQLLG------------------ 431
                    ||:.       |::|::....|      :..|...||.|                  
Yeast   611 VRIFANPGITDA-------LDNIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDN 668

  Fly   432 ------------HRFFLQYASTESAGAAANAEKPYFKLSLNAKELLKQAAIKSENRLRDE----- 479
                        |...::..|..|..:..|..:.|                 ..|..||.     
Yeast   669 TSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFY-----------------GSNNFRDNIASLT 716

  Fly   480 ------QKSVKNQKRIVRVQELMSSEEEKR--KSKQKAKLEHKQSK--LKQQSSIQTNNGRL 531
                  :|.::..:.::...:|.:::.:.:  |..|:..|:..:.|  ||||..:|.|...|
Yeast   717 ISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSL 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8726NP_610341.2 PX_MONaKA 13..132 CDD:132781 28/148 (19%)
Protein Kinases, catalytic domain 237..432 CDD:473864 47/302 (16%)
WH2 622..646 CDD:425359
MDM1NP_013603.1 PXA 85..276 CDD:214611 29/144 (20%)
RGS 462..567 CDD:470619 19/108 (18%)
PX_MDM1p 763..900 CDD:132786 7/16 (44%)
Nexin_C 993..1106 CDD:462541
Blue background indicates that the domain is not in the aligned region.

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