Protein Alignment CG8726 and SGK3

DIOPT Version :10

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_037389.4
• Gene: SGK3 / 23678
• HGNCID: 10812
• Length: 496
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 107/484 - (22%)
• Similarity: 173/484 - (35%)
• Gaps: 145/484 - (29%)

  Fly    21 SCEITAVQEVAGHTE-------YLLRVWRGASNKNYWTVLRRYNDFDRLDKSLR--VSGIELPLP 76
            ||...::.....|.|       |.:.|..|.|.   |.|.|||.:||:|..:|:  ...:.|.:|
Human    12 SCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSE---WFVFRRYAEFDKLYNTLKKQFPAMALKIP 73

  Fly    77 RKRIFG-NMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPESYSQSFHDHAVQNAMLCL 140
            .||||| |..|:||.:|:..|.|:|..::..|.|.:....:.|:..:|
Human    74 AKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDS----------------- 121

  Fly   141 RNDTTWSLGGSMGAIGWRLRKHYFKVTTKPPEKSSNKQLVKSGSQTHQ-SKHFAAGSSNGSGHS- 203
                               .||....:....|:||.|        .|. |::...|.| |:.|:
Human   122 -------------------PKHQSDPSEDEDERSSQK--------LHSTSQNINLGPS-GNPHAK 158

  Fly   204 ---------IDAGTLDPGSEVVAEWLEYGPDKF-----------IDEKEIGGIMKS----LMGLQ 244
                     |..|:.  |..::|:....|  ||           ::.||...||..    |..::
Human   159 PTDFDFLKVIGKGSF--GKVLLAKRKLDG--KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVK 219

  Fly   245 HPHIEPVLLAAHTENGCLVIRKFHKHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYG 309
            ||.:..:..:..|......:..|...|.    |......:.:|      |:.|...       |.
Human   220 HPFLVGLHYSFQTTEKLYFVLDFVNGGE----LFFHLQRERSF------PEHRARF-------YA 267

  Fly   310 KQILEALIFLHSKGYAYGHLHS--------GNIVIVD-----DCVKLLDIENFLLGVPAFYRPFF 361
            .:|..||.:|||....|..|..        |::|:.|     :.:.:.|......|.|.:..|..
Human   268 AEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEV 332

  Fly   362 MQHSKIHAIETIDVYCFGHVLFEMAMGYP---------LQESVVRQITECPEALK--------CL 409
            ::.....  .|:|.:|.|.||:||..|.|         :.::::.:    |.:|:        .:
Human   333 IRKQPYD--NTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPGVSLTAWSI 391

  Fly   410 LESILSKEACKAGLPTLEQLL---GHRFF 435
            ||.:|.|:. :..|...|..|   .|.||
Human   392 LEELLEKDR-QNRLGAKEDFLEIQNHPFF 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	36/120 (30%)
		Protein Kinases, catalytic domain	237..432	CDD:473864	46/231 (20%)
		WH2	622..646	CDD:425359
SGK3	NP_037389.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		2/8 (25%)
		PX_CISK	12..120	CDD:132780	35/110 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		12/79 (15%)
		STKc_SGK3	165..490	CDD:270755	59/283 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		2/9 (22%)