DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul3b

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001177414.1	Gene:	cul3b / 572370	ZFINID:	ZDB-GENE-081007-1	Length:	766	Species:	Danio rerio

Alignment Length:	833	Identity:	230/833 - (27%)
Similarity:	402/833 - (48%)	Gaps:	129/833 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRSGNSQTT------------QKLVNLDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFY 46
            :::.|..:.|            :|.||  :||..|...|.::.....|      |.|:.| |..:
Zfish     4 LSKGGTKKDTKMRIRAFPMTMDEKYVN--NIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLH 66

  Fly    47 THVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL----- 106
            .|                          |:|||..|.:.:..:   |:.|.:    |:||
Zfish    67 KH--------------------------GEKLYTGLREVVTEH---LINKVR----EDVLNSLNN 98

  Fly   107 --LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLN 167
              |....:.|..:|.:..::..|..|::|.:|:      |..:..:|.|.|:.::..:  :..:.
Zfish    99 NFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQ------QNNVENVYNLGLIIFRDQVVRYGCIR 157

  Fly   168 EPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTS 232
            :.:.:.:|..|..||:|::::|..:|:..:..:.|..         :..|||:::||..|:..::
Zfish   158 DHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGL---------EGRSVYEEDFEAPFLEMSA 213

  Fly   233 AFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEK 297
            .|::.||..||:.|:.:.|:|.||.|:.||.:||        :..|.::|.:.:....|..||.|
Zfish   214 EFFQMESQKFLAENSASVYIKKVEARINEEIERV--------IHCLDKSTEEPIVKVVERELISK 270

  Fly   298 HLKIFHTEFQN-----LLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTT 357
            |:|.. .|.:|     :|...:.:||..||.|.:.....|..:...:.:::..||...:::   .
Zfish   271 HMKTI-VEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSE---E 331

  Fly   358 DAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLA 422
            ....:|..|:|.:||:..:::..:..:||||..|...:......|:|.|        |:|||.|:
Zfish   332 GEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLN--------SRSPEYLS 388

  Fly   423 KYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMM 487
            .:.|..|||..|...::|:|..|::.||:|:::::||||::||.:.||:||:.:.|.|||:|..|
Zfish   389 LFIDDKLKKGVKGLTEQEVESILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNM 453

  Fly   488 ISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN 551
            |||||..||.::|.||:.||:|:.:|......|:|:|....::: .:|..:.||::|.||.|.:.
Zfish   454 ISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLTSTGVSLGGVDLIVRVLTTGYWPTQSAT 518

  Fly   552 -NFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELI------------------MNVNRN 597
             ...:|.....:...|..||.|:||||:|...:.|...:|.                  ..|..:
Zfish   519 PKCNIPPSPRHAFEVFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPIKKEDGSDMVGGAQVTGS 583

  Fly   598 NSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNE 658
            |:..:.||.|||||::|:.||::...|.:::|..|...:..|::.||.|...|    |||.....
Zfish   584 NTRKHILQVSTFQMTILMLFNNREKSTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKS 648

  Fly   659 NSLTPESTVELFLDYKNKKRRININ--QPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRK 721
            ..:.......:...:.::..|:.|.  ...:.|...|::...:.:::|||..|:||||||||.||
Zfish   649 KEIENGHVFTVNDQFTSRLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRK 713

  Fly   722 RLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ::.|..|::||..||..||.|...||||.|:.|||:|||.|....:..|:|:|
Zfish   714 KMQHNVLVAEVTQQLRARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	181/692 (26%)
		CULLIN	454..593	CDD:214545	52/158 (33%)
		Cullin_Nedd8	701..765	CDD:214883	35/63 (56%)
cul3b	NP_001177414.1	Cullin	34..662	CDD:279260	181/695 (26%)
		CULLIN	420..562	CDD:214545	52/141 (37%)
		Cullin_Nedd8	698..758	CDD:287520	33/59 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930