Protein Alignment Cul1 and cul3

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001015975.2
• Gene: cul3 / 548729
• XenbaseID: XB-GENE-974982
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 812
• Identity: 228/812 - (28%)
• Similarity: 395/812 - (48%)
• Gaps: 118/812 - (14%)

  Fly    11 QKLVNLDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHVYDYCTSVSAAPSGRSSGKT 68
            :|.||  .||..|...|.::.....|      |.|:.| |..:.|
 Frog    27 EKYVN--SIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKH-------------------- 69

  Fly    69 GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLDG 126
                  |:|||..|.:.:..:   |:.|.:    |:||       |....:.|..:|.:..::..
 Frog    70 ------GEKLYTGLREVVTEH---LINKVR----EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRD 121

  Fly   127 ICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLINR 189
            |..|::|.:|:      |..:..:|.|.|:.::..:  :..:.:.:.:.:|..|..||:|::::|
 Frog   122 ILMYMDRVYVQ------QNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR 180

  Fly   190 SLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKH 254
            ..:|:..:..:.|..         :..|||:::||..|:..::.|::.||..||:.|:.:.|:|.
 Frog   181 GAIRNACQMLMILGL---------EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 236

  Fly   255 VENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNADR 314
            ||.|:.||.:||        :..|.::|.:.:....|..||.||:|.. .|.:|     :|...:
 Frog   237 VEARINEEIERV--------MHCLDKSTEEPIVKVVERELISKHMKTI-VEMENSGLVHMLKNGK 292

  Fly   315 NDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNA 379
            .:||..||.|.:.....|..:...:..::..||...:::   .....:|..|:|.:||:..:::.
 Frog   293 TEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKALVSE---EGEGKNPVDYIQGLLDLKSRFDR 354

  Fly   380 LVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDN 444
            .:..:|:||..|...:......|:|.|        |:|||.|:.:.|..|||..|...::|:|..
 Frog   355 FLQESFSNDRLFKQTIAGDFEYFLNLN--------SRSPEYLSLFIDDKLKKGVKGLTEQEVESI 411

  Fly   445 LNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQD 509
            |::.||:|:::::||||::||.:.||:||:.:.|.|||:|..||||||..||.::|.||:.||:|
 Frog   412 LDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRD 476

  Fly   510 IGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFYAA 572
            :.:|......|:|:|....::: .:|..:.||::|.||.|.:. ...:|.....:...|..||.|
 Frog   477 MSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLA 541

  Fly   573 RHSGRKLNWLYQMCKGELI-------------------MNVNRNNSSTYTLQASTFQMSVLLQFN 618
            :||||:|...:.|...:|.                   ..|..:|:..:.||.|||||::|:.||
 Frog   542 KHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN 606

  Fly   619 DQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFLDYKNKKRR 679
            ::..:|.:::|..|...:..|::.||.|...|    |||.......:.......:...:.:|..|
 Frog   607 NREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHMFTVNDQFTSKLHR 671

  Fly   680 ININ--QPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
            :.|.  ...:.|...|::...:.:::|||..|:||||||||.||::.|..|::||..||..||.|
 Frog   672 VKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLP 736

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...||||.|:.|||:|||.|....:..|:|:|
 Frog   737 SPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	181/698 (26%)
		Cullin_Nedd8	704..765	CDD:463146	35/60 (58%)
cul3	NP_001015975.2	Cullin	34..665	CDD:459983	181/698 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		2/20 (10%)
		Cullin_Nedd8	698..760	CDD:463146	35/61 (57%)