DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and Cul1

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001342479.1	Gene:	Cul1 / 26965	MGIID:	1349658	Length:	776	Species:	Mus musculus

Alignment Length:	789	Identity:	493/789 - (62%)
Similarity:	599/789 - (75%)	Gaps:	32/789 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSV---------S 57
            |||.|.... |.:.||.||.:|..||.||:..: |:.:|:||..|||||:|||||         .
Mouse     4 NRSQNPHGL-KQIGLDQIWDDLRAGIQQVYTRQ-SMAKSRYMELYTHVYNYCTSVHQSNQARGAG 66

  Fly    58 AAPSGRSSGKT-GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSS 121
            ..||....|:| ||||.||.:||.||::|||:||:.||...:.:..|.| |..||:||:.|:|||
Mouse    67 VPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESV-LKFYTQQWEDYRFSS 130

  Fly   122 TVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKL 186
            .||:|||.||||:||:|||:||:||||:||.||||.|:..||:.||:.||.||||.||:||.|:.
Mouse   131 KVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGET 195

  Fly   187 INRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEY 251
            ||..|:..|::.||||..||:|..|:...|:|||::||::|:|||..||.:||..||..|.||||
Mouse   196 INTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEY 260

  Fly   252 LKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRND 316
            :|..|.||.||.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:|:
Mouse   261 MKKAEARLLEEQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNE 317

  Fly   317 DLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALV 381
            ||.|||:||:.....|.:||.:||.||.:||..||.||... |.||||.||||:|||||||||||
Mouse   318 DLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA-ALNDPKMYVQTVLDVHKKYNALV 381

  Fly   382 LTAFNNDNGFVAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNL 445
            ::|||||.|||||||||||:|||:|.|| :|.|:||||||||:|||.||||||||||:.||||.|
Mouse   382 MSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTL 446

  Fly   446 NQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDI 510
            ||||||||||||||||||:|:||||||||:..||||||||.|||||||.||:|||.|||||||||
Mouse   447 NQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDI 511

  Fly   511 GVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHS 575
            |||||||..||::|.... .:::||.|:||||||||||.|..|.||||||||.::|..|||:|||
Mouse   512 GVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHS 575

  Fly   576 GRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLI 640
            ||||.||||:.||||:.|..:|.   ||||||||||::|||:|.:.::|||||.|:||.:.:.|.
Mouse   576 GRKLTWLYQLSKGELVTNCFKNR---YTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILA 637

  Fly   641 QVLQILLKAKVLTSSD-----NENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKH 700
            ||||||||:|:|...|     :|..|.|::.::|:|.|||||.|:|||.|:|||.|.||||.||:
Mouse   638 QVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702

  Fly   701 IEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEG 765
            |||||||||||||||||||||.|.|..|:.|||.|||:||||:|||||||||||||||||||::|
Mouse   703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDG 767

  Fly   766 HKDTYSYLA 774
            .||||||||
Mouse   768 EKDTYSYLA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	400/663 (60%)
		CULLIN	454..593	CDD:214545	100/138 (72%)
		Cullin_Nedd8	701..765	CDD:214883	53/63 (84%)
Cul1	NP_001342479.1	Cullin	21..660	CDD:395716	399/654 (61%)
Cul1	NP_001342479.1	Cullin_Nedd8	706..767	CDD:402267	50/60 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849220
Domainoid	1	1.000	757	1.000	Domainoid score	I86
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2663
Inparanoid	1	1.050	931	1.000	Inparanoid score	I350
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	1	1.000	-	-		oto93647
orthoMCL	1	0.900	-	-		OOG6_101330
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R262
SonicParanoid	1	1.000	-	-		X1841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800