DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and Cul3

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_057925.1	Gene:	Cul3 / 26554	MGIID:	1347360	Length:	768	Species:	Mus musculus

Alignment Length:	812	Identity:	229/812 - (28%)
Similarity:	395/812 - (48%)	Gaps:	118/812 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QKLVNLDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHVYDYCTSVSAAPSGRSSGKT 68
            :|.||  .||..|...|.::.....|      |.|:.| |..:.|
Mouse    27 EKYVN--SIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKH-------------------- 69

  Fly    69 GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLDG 126
                  |:|||..|.:.:..:   |:.|.:    |:||       |....:.|..:|.:..::..
Mouse    70 ------GEKLYTGLREVVTEH---LINKVR----EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRD 121

  Fly   127 ICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLINR 189
            |..|::|.:|:      |..:..:|.|.|:.::..:  :..:.:.:.:.:|..|..||:|::::|
Mouse   122 ILMYMDRVYVQ------QNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR 180

  Fly   190 SLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKH 254
            ..:|:..:..:.|..         :..|||:::||..|:..::.|::.||..||:.|:.:.|:|.
Mouse   181 GAIRNACQMLMILGL---------EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 236

  Fly   255 VENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNADR 314
            ||.|:.||.:||        :..|.::|.:.:....|..||.||:|.. .|.:|     :|...:
Mouse   237 VEARINEEIERV--------MHCLDKSTEEPIVKVVERELISKHMKTI-VEMENSGLVHMLKNGK 292

  Fly   315 NDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNA 379
            .:||..||.|.:.....|..:...:..::..||...:::   .....:|..|:|.:||:..:::.
Mouse   293 TEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSE---EGEGKNPVDYIQGLLDLKSRFDR 354

  Fly   380 LVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDN 444
            .:..:||||..|...:......|:|.|        |:|||.|:.:.|..|||..|...::|:|..
Mouse   355 FLQESFNNDRLFKQTIAGDFEYFLNLN--------SRSPEYLSLFIDDKLKKGVKGLTEQEVETI 411

  Fly   445 LNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQD 509
            |::.||:|:::::||||::||.:.||:||:.:.|.|||:|..||||||..||.::|.||:.||:|
Mouse   412 LDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRD 476

  Fly   510 IGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFYAA 572
            :.:|......|:|:|....::: .:|..:.||::|.||.|.:. ...:|.....:...|..||.|
Mouse   477 MSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLA 541

  Fly   573 RHSGRKLNWLYQMCKGELI-------------------MNVNRNNSSTYTLQASTFQMSVLLQFN 618
            :||||:|...:.|...:|.                   ..|..:|:..:.||.|||||::|:.||
Mouse   542 KHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN 606

  Fly   619 DQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFLDYKNKKRR 679
            ::..:|.:::|..|...:..|::.||.|...|    |||.......:.......:...:.:|..|
Mouse   607 NREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHR 671

  Fly   680 ININ--QPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
            :.|.  ...:.|...|::...:.:::|||..|:||||||||.||::.|..|::||..||..||.|
Mouse   672 VKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLP 736

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...||||.|:.|||:|||.|....:..|:|:|
Mouse   737 SPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	181/693 (26%)
		CULLIN	454..593	CDD:214545	52/159 (33%)
		Cullin_Nedd8	701..765	CDD:214883	35/63 (56%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250\|UniProtKB:Q13618	2..41		6/15 (40%)
		Cullin	35..664	CDD:279260	181/696 (26%)
		CULLIN	421..563	CDD:214545	52/141 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		2/20 (10%)
		Cullin_Nedd8	700..760	CDD:287520	33/59 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820