Protein Alignment Cul1 and cul-1

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_499309.1
• Gene: cul-1 / 176466
• WormBaseID: WBGene00000836
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 797
• Identity: 335/797 - (42%)
• Similarity: 488/797 - (61%)
• Gaps: 47/797 - (5%)

  Fly     6 NSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGR------- 63
            ||:..:...:.:.:|.:|.:|:...:..| ::....||..||.|||||||::.:.|.|
 Worm     3 NSEPRRMTCDSEVVWKKLQDGLDVAYRRE-NMAPKDYMTLYTSVYDYCTSITLSTSRRDGEDGRA 66

  Fly    64 ---SSGKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLD 125
               :..:|.||..||.::|.|:|:::|:|:..:..|...:|||: ||..||.:|::::.||.|:|
 Worm    67 ESSTPARTAGADFVGHEMYQRVEEYVKAYVIAVCEKGAELSGED-LLKYYTTEWENFRISSKVMD 130

  Fly   126 GICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRS 190
            ||..||||:|::||.:||.:.||.:|.||||.||.:||..|.:.|..|:|:.|..||.|.:||..
 Worm   131 GIFAYLNRHWIRRELDEGHENIYMVYTLALVVWKRNLFNDLKDKVIDAMLELIRSERTGSMINSR 195

  Fly   191 LVRDVIECYVELSFNEEDT----DAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLST-NTVTE 250
            .:..|:||.|||..::.:|    |||.:||:|||:.||.||:..|..||.:|:..|||. ..||:
 Worm   196 YISGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTD 260

  Fly   251 YLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRN 315
            |:..||.||.:|..|.:        .||:.:|...|.:.||.|||...|......|..||...|:
 Worm   261 YMIKVETRLNQEDDRCQ--------LYLNSSTKTPLATCCESVLISNQLDFLQRHFGGLLVDKRD 317

  Fly   316 DDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNAL 380
            |||.||:.|.......|.:|:..|||||..:|.:|:.: ...:||.|.|.||:|:|:||::|.:|
 Worm   318 DDLSRMFKLCDRVPNGLDELRKSLENHIAKEGHQALER-VAMEAATDAKLYVKTLLEVHERYQSL 381

  Fly   381 VLTAFNNDNGFVAALDKACGKFINSNVVT----IANSASKSPELLAKYCDLLLKKSSKNPEDKEL 441
            |..:|.|:.||:.:||||...|||:|.||    .....:||.||||:|||.||:||||.|::.||
 Worm   382 VNRSFKNEPGFMQSLDKAATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRKSSKMPDEAEL 446

  Fly   442 EDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRM 506
            |:...::|||||||:|||||.|:|:||.:|||::..||||:|||..|:|||..||||||.:|.:|
 Worm   447 EELQTKIMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKM 511

  Fly   507 FQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYA 571
            ..|..|||||.:.||:..|:......::|.:.||||||||...:....||.:|.:::..|.:||.
 Worm   512 VNDTQVSKDLTADFKEKKADMLGQKSVEFNVLVLSSGSWPTFPTTPITLPQQLSKTIEIFGQFYN 576

  Fly   572 ARHSGRKLNWLYQMCKGELIMNVNRNNSST-----YTLQASTFQMSVLLQFNDQLSFTVQQLQDN 631
            .:.:||:|.|:|...:||:        :||     |...|:|.||..:|.||:|.|:||:|:...
 Worm   577 EKFNGRRLTWVYSQSRGEI--------TSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQIAAA 633

  Fly   632 TQTQQENLIQVLQILLKAKVL---TSSDNENSLTPESTVELFLDYKNKKRRININQ-PLKTELKV 692
            |:..:::...::..|:|..||   |....|:.:...:||.|...|.|||.|::::: .:|.:...
 Worm   634 TKMDEKSAPAIVGSLIKNLVLKADTELQKEDEVPMTATVSLNKAYMNKKVRVDLSKFTMKQDAVR 698

  Fly   693 EQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEK 757
            :.|.|.|::|||||.:|.|.||||||.|||:.|..|::||:.|||.||||||.:||:||..||||
 Worm   699 DTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEK 763

  Fly   758 EYLERMEGHKDTYSYLA 774
            ||:.|.||.||.|.|||
 Worm   764 EYMLRTEGQKDLYEYLA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	276/679 (41%)
		Cullin_Nedd8	704..765	CDD:463146	38/60 (63%)
cul-1	NP_499309.1	Cullin	17..678	CDD:459983	276/679 (41%)
		Cullin_Nedd8	710..772	CDD:463146	39/61 (64%)