Protein Alignment Cul1 and anapc2

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_031746476.1
• Gene: anapc2 / 101731339
• XenbaseID: XB-GENE-491168
• Length: 811
• Species: Xenopus tropicalis
• Alignment Length: 847
• Identity: 162/847 - (19%)
• Similarity: 296/847 - (34%)
• Gaps: 247/847 - (29%)

  Fly    32 EHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGG--AQLVGKKLYDRLEQFL----KSYL 90
            ||...|....:....:.:..|..|:........:|..|.  :|::..|:|...:..|    .|:.
 Frog    94 EHCAVLLLDAFRLLVSRLEPYLRSLDILAKWIDTGLLGSSDSQMLRDKVYTMFKAILFFSTSSHF 158

  Fly    91 SELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLD-----GICNYLNRN-------------WVK 137
            .:::.:|            |::.:|.|.......|     |..:.:|.|             |..
 Frog   159 QDMIQQF------------YSRTFKIYMKQRKRGDGGGGGGSDSSMNENERESDSDERGADEWQC 211

  Fly   138 RECEEGQKGIYKIYRLALVAWKGHLFQVLN-------EPVTKAVLKSIEEERQGKLINRSLVRDV 195
            ..||..:...:.:..:........:|..||       :.||..:.|.|||..:.:
 Frog   212 PGCESSRDQCWCLCAMGQFQQLSDIFHRLNLLERICSDAVTTILHKMIEERMEKR---------- 266

  Fly   196 IECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKE----SDAFLSTNTV-------T 249
              |                     :..:|..|:.:...:.||.    |..||...||       :
 Frog   267 --C---------------------RGEYERSFLGEFQEWIEKVIGWLSKVFLQDGTVPPTTPETS 308

  Fly   250 EYLK----HVEN---------RLEEETQRVRGF-NSKNGLSYLHETTADVLKSTCEEVLIEKHLK 300
            ..||    ||:.         |:||....:|.| .||..:
 Frog   309 STLKRWRCHVQRFFYRLYASMRIEELFNIIRDFPESKPAI------------------------- 348

  Fly   301 IFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKT 365
                           :|||..........:.||.||:.||..:||.|..      |:|...   .
 Frog   349 ---------------EDLKFCLERTNQRQQLLTSLKNALETRLLHPGVN------TSDIIT---L 389

  Fly   366 YVQTILDVHKKYNALVLTAFNNDNGFVAALDKAC---GKFINSN-------VVTIANSASKSPEL 420
            |:..|..:.:...::|:            |:.||   .|::.:.       |..:...|..|.:|
 Frog   390 YISAIKALRELDPSMVI------------LEVACEPIRKYLRTREDTVRQIVAGLTGDAEGSADL 442

  Fly   421 ---LAKYCDLLLKKSSKNPED-KELEDNL------------------NQVMVVFKYIEDKDVFQK 463
               |:| .|.:|:...::.:| .|.||.|                  :.:.::......|::|..
 Frog   443 ANELSK-ADPVLENGQESDDDVSEAEDWLPDPVDADPGKSSSKRRSSDIISLLVSIYGSKELFIN 506

  Fly   464 YYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKN 528
            .|..:||:||::..:.|.:.|...:..||...|.......:.|.:|:..|:.:||..:.  .|:.
 Frog   507 EYRTLLAERLLHQFNYSSEREIRNVELLKLRFGEAQMHYCEVMLKDMADSRRINSNIRD--EEEK 569

  Fly   529 LTME----IDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGE 589
            |..|    .:....:|||..||........||.|::..:..:.:.|....:.|.|||.:.:  |.
 Frog   570 LPEEERPPFNVVAVILSSEFWPALKEEKLELPDEIKEVMDMYTKKYEKLKAMRTLNWKHHL--GL 632

  Fly   590 LIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAKVL-- 652
            ::::|...: .|.:...|....:::|.|.::.::|:::|.:..:....:|.:.:...|:..||
 Frog   633 VVLDVELAD-RTLSFPVSPVHAAIILHFQNKSTWTLEELSEVLKVPVASLRKKMAFWLQHGVLRE 696

  Fly   653 ------TSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLL--- 708
                  |..:.|....||..|.:..|.:......:         :.:|:      ||:.:|.
 Frog   697 DPPGTFTVIEEEQKDRPEKVVLIDSDEEGDSAMAS---------QADQK------EEEMQLFWTY 746

  Fly   709 IQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKV---PVIKKCIDILIEKEYLE-RMEGHKDT 769
            |||.:            |||.|..|.::.|..|..|   ||:.: |||...:.:|: ::..|:..
 Frog   747 IQAML------------TNLESLPLERIHTMLKMFVMTGPVVTE-IDIQELQSFLQKKVSDHQLV 798

  Fly   770 YS 771
            ||
 Frog   799 YS 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	137/736 (19%)
		CULLIN	454..593	CDD:214545	34/142 (24%)
		Cullin_Nedd8	701..765	CDD:214883	20/70 (29%)
anapc2	XP_031746476.1	CULLIN	498..635	CDD:214545	34/140 (24%)
		ANAPC2	746..806	CDD:400832	20/68 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910