Protein Alignment Rpt1 and Katna1

DIOPT Version :10

• Sequence 1: NP_477473.1
• Gene: Rpt1 / 35701
• FlyBaseID: FBgn0028687
• Length: 433
• Species: Drosophila melanogaster
• Sequence 2: NP_035965.3
• Gene: Katna1 / 23924
• MGIID: 1344353
• Length: 491
• Species: Mus musculus
• Alignment Length: 469
• Identity: 136/469 - (28%)
• Similarity: 204/469 - (43%)
• Gaps: 93/469 - (19%)

  Fly    28 GDIELLKTYGQ------SQYHKSIK---------SIEEDIQKAVKQVNELTGIKES--------- 68
            |:.:....|.|      ::|..|:|         .:.::|....|||.::....||
Mouse    20 GNYDSAMVYYQGVLDQMNKYLYSVKDTHLRQKWQQVWQEINVEAKQVKDIMKTLESFKLDITSLQ 84

  Fly    69 ----DTGLAPPALWDLAA-----------DKQILQNEQPLQVA-RCTKIINADSDDPKYIINVKQ 117
                :...|...:|.|..           .:|..|:..|...: |.:.::.|....|:.:.|
Mouse    85 AAQHEFPAAEGEVWSLPVPVERRPLPGPRKRQSSQHSDPKPHSNRPSTVVRAHRPSPQNLHN--- 146

  Fly   118 FAKFVVDLADSVAPTDIEEGMRVGVDRNKYQIHIPLPP--KIDPT------VTMMQ---VEDKPD 171
                  |...:|...:.:|..:...::||....:..|.  |.|.|      |..::   :...|:
Mouse   147 ------DRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDGTGYDKDLVEALERDIISQNPN 205

  Fly   172 VTYSDVGGCKEQIEKLREVVETPLLHPEKFVNLGIEPP-KGVLLFGPPGTGKTLCARAVANRTDA 235
            |.:.|:....|..:.|:|.|..|:..||.|  .||..| ||||:.|||||||||.|:|||.....
Mouse   206 VRWYDIADLVEAKKLLQEAVVLPMWMPEFF--KGIRRPWKGVLMVGPPGTGKTLLAKAVATECKT 268

  Fly   236 CFIRVIGSELVQKYVGEGARMVRELFEMARSKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTM- 299
            .|..|..|.|..||.||..::||.||||||......||.||||:|...|   |...::|..|.|
Mouse   269 TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRR---GTSEEHEASRRMK 330

  Fly   300 LELINQLDGF-------DPRGNIKVLMATNRPDTLDPALMRPGRLDRKVEFGLPDQDGRSHIFKI 357
            .||:.|:||.       ||...:.||.|||.|..:|.||.|  ||::::...||...||..:.:|
Mouse   331 AELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRI 393

  Fly   358 HARSMSVERDIRFDLLARLCPNSTGAEIRSVCTEAGMFAIRAR---------RKVATE------- 406
            ..|.:.:..|:....:|......:||:|.:||.:|.:.|:|.|         |.::.|
Mouse   394 SLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREAMHMPTT 458

  Fly   407 -KDFLEAVKKVIKS 419
             :||..|:||:.||
Mouse   459 MEDFEMALKKISKS 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt1	NP_477473.1	PRK03992	88..430	CDD:179699	120/370 (32%)
Katna1	NP_035965.3	Interaction with microtubules, sufficient for microtubule severing activity. /evidence=ECO:0000269|PubMed:28436967	1..185		30/173 (17%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75		10/54 (19%)
		Interaction with KATNB1	1..29		1/8 (13%)
		Kp60-NTD	4..72	CDD:439297	10/51 (20%)
		SpoVK	61..469	CDD:440232	126/423 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..182		13/89 (15%)
		RecA-like_KTNA1	210..379	CDD:410930	76/175 (43%)
		Vps4_C	<456..489	CDD:462762	7/17 (41%)