Protein Alignment az2 and ZNF181

DIOPT Version :10

• Sequence 1: NP_610289.2
• Gene: az2 / 35682
• FlyBaseID: FBgn0025185
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_001025168.2
• Gene: ZNF181 / 339318
• HGNCID: 12971
• Length: 571
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 131/619 - (21%)
• Similarity: 217/619 - (35%)
• Gaps: 189/619 - (30%)

  Fly    24 NDCYVEMEFKRWREFIVHVKEHLEANPSMQQELTTSEVISSAKCEEEVSPA-----KVFIV---- 79
            ||..::...:.|...           .|.|::|....::.:  .|..||.|     |.:::
Human     7 NDVAIDFTHEEWGWL-----------SSAQRDLYKDVMVQN--YENLVSVAGLSVTKPYVITLLE 58

  Fly    80 --EEP--PENCLAEDMFVDVPPSSENDESTSPVEEEEEEDDEVDSSSMTVDCELGTRNSTHFAPL 140
              :||  .|..|::.|..|.....||.|.::      ::|:..:.|..||..|...:.|..|:
Human    59 DGKEPWMMEKKLSKGMIPDWESRWENKELST------KKDNYDEDSPQTVIIEKVVKQSYEFS-- 115

  Fly   141 TKFNPTFYRRSPRITQFIE----LYKQQTCLWDPADESYRDKEKRANAYEELLEQLKATVNLHLT 201
                     .|.:..::||    .:..|...:.||..:.|:.....:.|:         .|:..:
Human   116 ---------NSKKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYK---------YNIFRS 162

  Fly   202 AYKLKKCITSLHAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDADSDDVDGDGKIKLV- 265
            .:..|..:    ::...||.:..:.           ||..|.:....:....::....|| ||:
Human   163 TFHSKSTL----SEPQKISAEGNSH-----------KYDILKKNLPKKSVIKNEKVNGGK-KLLN 211

  Fly   266 -------FTEENQLTTQFIDLYSKFPQ------LYDPAHKHFCNLNVRKSSLIEITDLLTSEFSL 317
                   |::...||         .||      :|..:.   |.....|.|::.
Human   212 SNKSGAAFSQGKSLT---------LPQTCNREKIYTCSE---CGKAFGKQSILN----------- 253

  Fly   318 GLVTHYDVYDSIQSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKL------- 375
                           |.|   ||.|           .||.|  .|.....|.|....|
Human   254 ---------------RHW---RIHT-----------GEKPY--ECRECGKTFSHGSSLTRHLISH 287

  Fly   376 ------KCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQHSQRVH-MDKS 433
                  ||..|..:||...:|..||  ....|:.. :.|..|..:|.|..||.:| .|:| .:|.
Human   288 SGEKPYKCIECGKAFSHVSSLTNHQ--STHTGEKP-YECMNCGKSFSRVSHLIEH-LRIHTQEKL 348

  Fly   434 FVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHV-------------- 484
            :.|.||.::|...:.|..|::.|..:   ||:.|..|||.|.....:|.|.
Human   349 YECRICGKAFIHRSSLIHHQKIHTGE---KPYECRECGKAFCCSSHLTRHQRIHTMEKQYECNKC 410

  Fly   485 -------------TAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANA 536
                         .::||:.:.|:|..|.|.|.....|..|::.|:.::...|.:|.|||::.::
Human   411 LKVFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSICGKAFSHRSS 475

  Fly   537 LVKHRHIHK-EKTLQCSLCTTRFSERVSLGVHMR 569
            |::|..||. ||..:|..|...||...:|.||.|
Human   476 LLQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQR 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:463144	13/88 (15%)
		MADF_DNA_bdg	276..>341	CDD:463144	9/70 (13%)
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..488	CDD:275368	7/47 (15%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..572	CDD:275368	8/19 (42%)
ZNF181	NP_001025168.2	KRAB	4..65	CDD:214630	13/70 (19%)
		COG5048	211..>539	CDD:227381	85/360 (24%)
		C2H2 Zn finger	239..259	CDD:275368	6/51 (12%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	7/21 (33%)
		C2H2 Zn finger	323..343	CDD:275368	8/20 (40%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..427	CDD:275368	0/19 (0%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368