Protein Alignment az2 and ZNF569

DIOPT Version :10

• Sequence 1: NP_610289.2
• Gene: az2 / 35682
• FlyBaseID: FBgn0025185
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: XP_006723109.1
• Gene: ZNF569 / 148266
• HGNCID: 24737
• Length: 710
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 129/539 - (23%)
• Similarity: 205/539 - (38%)
• Gaps: 116/539 - (21%)

  Fly    97 PSSENDESTS----------PVEEEEEEDDEVDSSSMTVDCELGTRNSTHFA----PLTKFNPTF 147
            ||.:.:|.|.          .::..:||...:|.:...:...:...|..:..    |.||.:..|
Human    18 PSQKEEEMTESQGTVTFKDVAIDFTQEEWKRLDPAQRKLYRNVMLENYNNLITVGYPFTKPDVIF 82

  Fly   148 ---YRRSPRITQFIELYKQ-QTCLWDPADESYRDKEKRANAYEELLEQLKATVNLHLTAYKLKKC 208
               ....|.:.:...|.:. |..:|. .||..:::::       ||.|::......||..|..:|
Human    83 KLEQEEEPWVMEEEVLRRHWQGEIWG-VDEHQKNQDR-------LLRQVEVKFQKTLTEEKGNEC 139

  Fly   209 ITSLHAQYASISRQKKTQKLTKVPLYYHGKYSFLAERGSLEDAD------SDDVDGDGKIKLVFT 267
                         |||...:  .||    ...|...|.:|.:.|      ..:.|....:|.:..
Human   140 -------------QKKFANV--FPL----NSDFFPSRHNLYEYDLFGKCLEHNFDCHNNVKCLMR 185

  Fly   268 EENQLTTQFIDLYSKFPQLYDPAHKHF------CN-----LNVRKSSLIEITDLLTSE------- 314
            :|:       ..|::..:.|..:..||      ||     .| :...||....:.|.|
Human   186 KEH-------CEYNEPVKSYGNSSSHFVITPFKCNHCGKGFN-QTLDLIRHLRIHTGEKPYECSN 242

  Fly   315 ----FS--LGLVTHYDVYDSIQSMR--QWYSRRIKTLTDVQCVGLSLAEKQY-IERCNSFMPTKS 370
                ||  ..|:.||.::...||.:  :.....||....::...:...||.| .:.|.     ||
Human   243 CRKAFSHKEKLIKHYKIHSREQSYKCNECGKAFIKMSNLIRHQRIHTGEKPYACKECE-----KS 302

  Fly   371 FRQK---------------LKCEVCEHSFSTDHALQAHQFRDHKMGDGGW-FRCTLCELNFDRKC 419
            |.||               .:|..|..:||...:|.|||    |:..|.. :.|..|...|.|..
Human   303 FSQKSNLIDHEKIHTGEKPYECNECGKAFSQKQSLIAHQ----KVHTGEKPYACNECGKAFPRIA 363

  Fly   420 HLQQHSQRVHMDKSFVCEICSRSFAFGNQLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHV 484
            .|..|.:....:|.:.|:.|.::|:..:.|.||.|.|..:   ||:.|..|||.|.|...:|.|:
Human   364 SLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGE---KPYECNECGKAFSQSSALTVHM 425

  Fly   485 TAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKHRHIHK-EKT 548
            .: ||..:.::|..|.|.|..|::...|.|.|...:...|..|.|||...:.||:|:.||. ||.
Human   426 RS-HTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKP 489

  Fly   549 LQCSLCTTRFSERVSLGVH 567
            ..|..|...||::.:|..|
Human   490 YICKECGKAFSQKSNLIAH 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:463144	17/85 (20%)
		MADF_DNA_bdg	276..>341	CDD:463144	18/90 (20%)
		C2H2 Zn finger	377..398	CDD:275368	8/20 (40%)
		C2H2 Zn finger	408..429	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..488	CDD:275368	8/20 (40%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..572	CDD:275368	6/17 (35%)
ZNF569	XP_006723109.1	KRAB	32..86	CDD:214630	8/53 (15%)
		COG5048	<200..368	CDD:227381	42/177 (24%)
		C2H2 Zn finger	212..232	CDD:275368	5/20 (25%)
		C2H2 Zn finger	240..260	CDD:275368	5/19 (26%)
		C2H2 Zn finger	268..288	CDD:275368	2/19 (11%)
		COG5048	292..704	CDD:227381	71/230 (31%)
		C2H2 Zn finger	296..316	CDD:275368	6/24 (25%)
		C2H2 Zn finger	324..344	CDD:275368	9/23 (39%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		C2H2 Zn finger	408..428	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		C2H2 Zn finger	492..512	CDD:275368	6/17 (35%)
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	548..568	CDD:275368
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		C2H2 Zn finger	632..652	CDD:275368
		C2H2 Zn finger	660..680	CDD:275368
		C2H2 Zn finger	688..708	CDD:275368