DRSC/TRiP Functional Genomics Resources

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Protein Alignment az2 and ZNF729

DIOPT Version :10

Sequence 1:NP_610289.2 Gene:az2 / 35682 FlyBaseID:FBgn0025185 Length:593 Species:Drosophila melanogaster
Sequence 2:NP_001229609.1 Gene:ZNF729 / 100287226 HGNCID:32464 Length:1252 Species:Homo sapiens


Alignment Length:689 Identity:153/689 - (22%)
Similarity:238/689 - (34%) Gaps:234/689 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 IVHVKEH----LEANPSMQQ--ELTTSEVISSA----KCEE---------EVSPAKVFIVEEPPE 84
            |:|..|.    .|...:.:|  .||..:.|.:.    ||||         ::...|:....:.|.
Human   452 IIHTGEKPYKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSDLRRHKIIHTGKKPY 516

  Fly    85 NCLAEDMFVDVPPSS--ENDE----STSPVEEEEEEDDEVDSSSMTV-----------DCELGTR 132
            .|  |:.......||  .|.:    ...|.:.||.......||.:||           .||...:
Human   517 KC--EECGKAFSQSSTLRNHQIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCKCEECGK 579

  Fly   133 NSTHFAPLTKFNPTFYRRSPRITQFIELYKQQTCLWDPADESYRDKE-----------KRANAYE 186
            ...||:.|.|......|.        :|||.:.|     .:::.:..           |:....|
Human   580 AFKHFSALRKHKVIHTRE--------KLYKCEEC-----GKAFNNSSILAKHKIIHTGKKPYKCE 631

  Fly   187 ELLEQLKATVNLHLT----------AYKLKKCITSLHAQYASISRQKKTQKLTKVPLYYHGKYSF 241
            |..:..:.  :.|||          .||.::| ....:.::::.|.|         :.:.||..:
Human   632 ECGKAFRQ--SSHLTRHKAIHTGEKPYKCEEC-GKAFSHFSALRRHK---------IIHTGKKPY 684

  Fly   242 LAERGSLEDADSDDVDGDGKI----------KLVFTEE---------------NQLTTQFIDLYS 281
            ..|.             .||.          |::.|.|               ::||...:...:
Human   685 KCEE-------------CGKAFSHFSALRRHKIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTA 736

  Fly   282 KFP---QLYDPAHKHFCNLNVRKSSLIEITDLLTSEFSLGLVTHYDVYDSIQSMRQWYSRRIKTL 343
            :.|   :....:.|||..|  ||..:|...:.|           |...:.:::... :|..:|..
Human   737 EKPCKCEECGKSFKHFSAL--RKHKVIHTREKL-----------YKCEECVKAFNS-FSALMKHK 787

  Fly   344 TDVQCVGLSLAEKQY-IERCNSFMPTKSFR--QKL-------------KCEVCEHSFSTDHALQA 392
            .      :...||.| .|.|.     |:|:  .||             |||.|..:|....||  
Human   788 V------IHTGEKPYKCEECG-----KAFKWSSKLTVHKVIHTGEKPCKCEECGKAFKHFSAL-- 839

  Fly   393 HQFRDHKMGDGGW--FRCTLCELNFDRKCHLQQHSQRVHM-DKSFVCEICSRSFAFGNQLAIHKR 454
               |.||:...|.  ::|..|...|.:...|::| :.:|. :|.:.||.|.::|.:.::|.:||.
Human   840 ---RKHKVIHTGKKPYKCEECGKAFSQSSSLRKH-EIIHSGEKPYKCEECGKAFKWLSKLTVHKV 900

  Fly   455 THDE-------------KHVA----------------------------------------KPFV 466
            .|..             ||.:                                        ||:.
Human   901 IHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNDSSTLMKHKIIHTGKKPYK 965

  Fly   467 CEFCGKCFKQKIQMTTHVTAVHTKIRAFKCDMCPKDFLTKRDLKDHVKAHLNIRDKV--CEVCQK 529
            |..|||.|||...:|.| .|:||..:.:||:.|.|||.....||.|...|  .|:|:  ||.|.|
Human   966 CAECGKAFKQSSHLTRH-KAIHTGEKPYKCEECGKDFNNSSTLKKHKLIH--TREKLYKCEECVK 1027

  Fly   530 AFTNANALVKHRHIHK-EKTLQCSLCTTRFSERVSLGVH 567
            ||.|.:||:||:.||. ||..:|..|...|.....|..|
Human  1028 AFNNFSALMKHKIIHTGEKPYKCEECGKAFKWSSKLTEH 1066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
az2NP_610289.2 MADF_DNA_bdg 157..242 CDD:463144 17/105 (16%)
MADF_DNA_bdg 276..>341 CDD:463144 11/67 (16%)
C2H2 Zn finger 377..398 CDD:275368 7/20 (35%)
C2H2 Zn finger 408..429 CDD:275368 5/20 (25%)
C2H2 Zn finger 436..456 CDD:275368 7/19 (37%)
C2H2 Zn finger 467..488 CDD:275368 10/20 (50%)
C2H2 Zn finger 496..516 CDD:275368 8/19 (42%)
C2H2 Zn finger 524..544 CDD:275368 11/19 (58%)
C2H2 Zn finger 551..572 CDD:275368 5/17 (29%)
ZNF729NP_001229609.1 KRAB 13..73 CDD:214630
C2H2 Zn finger 182..202 CDD:275368
C2H2 Zn finger 210..230 CDD:275368
C2H2 Zn finger 239..258 CDD:275368
COG5048 262..666 CDD:227381 46/231 (20%)
C2H2 Zn finger 266..286 CDD:275368
C2H2 Zn finger 294..314 CDD:275368
C2H2 Zn finger 322..342 CDD:275368
C2H2 Zn finger 351..370 CDD:275368
C2H2 Zn finger 378..398 CDD:275368
C2H2 Zn finger 406..426 CDD:275368
C2H2 Zn finger 434..454 CDD:275368 1/1 (100%)
C2H2 Zn finger 462..482 CDD:275368 4/19 (21%)
C2H2 Zn finger 490..510 CDD:275368 4/19 (21%)
C2H2 Zn finger 518..538 CDD:275368 5/21 (24%)
C2H2 Zn finger 546..566 CDD:275368 6/19 (32%)
C2H2 Zn finger 574..594 CDD:275368 6/19 (32%)
C2H2 Zn finger 602..622 CDD:275368 1/24 (4%)
COG5048 625..1123 CDD:227381 116/501 (23%)
C2H2 Zn finger 630..650 CDD:275368 5/21 (24%)
C2H2 Zn finger 658..678 CDD:275368 3/29 (10%)
C2H2 Zn finger 686..706 CDD:275368 4/32 (13%)
C2H2 Zn finger 714..734 CDD:275368 2/19 (11%)
C2H2 Zn finger 742..762 CDD:275368 6/21 (29%)
C2H2 Zn finger 770..790 CDD:275368 2/26 (8%)
C2H2 Zn finger 798..818 CDD:275368 6/24 (25%)
C2H2 Zn finger 826..846 CDD:275368 9/24 (38%)
C2H2 Zn finger 854..874 CDD:275368 5/20 (25%)
C2H2 Zn finger 882..902 CDD:275368 7/19 (37%)
C2H2 Zn finger 910..930 CDD:275368 2/19 (11%)
C2H2 Zn finger 938..958 CDD:275368 0/19 (0%)
C2H2 Zn finger 966..986 CDD:275368 10/20 (50%)
C2H2 Zn finger 994..1014 CDD:275368 8/19 (42%)
C2H2 Zn finger 1022..1042 CDD:275368 11/19 (58%)
C2H2 Zn finger 1050..1070 CDD:275368 5/17 (29%)
C2H2 Zn finger 1078..1098 CDD:275368
C2H2 Zn finger 1106..1126 CDD:275368
zf-H2C2_2 1119..1143 CDD:463886
C2H2 Zn finger 1134..1154 CDD:275368
C2H2 Zn finger 1162..1182 CDD:275368
zf-H2C2_2 1174..1199 CDD:463886
C2H2 Zn finger 1190..1210 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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