Protein Alignment Br140 and MLLT10

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001182555.1
• Gene: MLLT10 / 8028
• HGNCID: 16063
• Length: 1068
• Species: Homo sapiens
• Alignment Length: 1211
• Identity: 258/1211 - (21%)
• Similarity: 406/1211 - (33%)
• Gaps: 410/1211 - (33%)

  Fly   286 CCICLDGECQNTNVILFCD--MCNLAVHQDCYGVPYIPEGQWLCRRC-LQSPSKPVNCVLCPNAG 347
            ||:|.|......|.:::||  .|::||||.|||:..:|.|.|.||:| .|..:..|.|.|||:..
Human    25 CCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKD 89

  Fly   348 GAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKG------LGA 406
            ||.|:||:|.||||||||:||||:|||...:||| .::::|..|:..|||:|.|:|      .||
Human    90 GALKRTDNGGWAHVVCALYIPEVQFANVSTMEPI-VLQSVPHDRYNKTCYICDEQGRESKAATGA 153

  Fly   407 CIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTPADAKLK------- 464
            |:.|:::.|..||||||||.|||      :.:...:.:.:||...||..|.   :|||
Human   154 CMTCNKHGCRQAFHVTCAQFAGL------LCEEEGNGADNVQYCGYCKYHF---SKLKKSKRGSN 209

  Fly   465 ----MNVPDF-----------EDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQ 514
                .::.|.           |..::|.|:..|...||:......|:|::            |:.
Human   210 RSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSL------------TVT 262

  Fly   515 RKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQ 579
            .:|.:                        .|..|       |.|.||
Human   263 TEKTY------------------------TSTSN-------NSISGS------------------ 278

  Fly   580 DLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEAR------------DS 632
                       :::.|.....|...:.:.|       .|..:...|..|.|            .|
Human   279 -----------LKRLEDTTARFTNANFQEV-------SAHTSSGKDVSETRGSEGKGKKSSAHSS 325

  Fly   633 MQIFREPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVF 697
            .|..|:| .....|..|.....|...|:........:.:|...:::.     |:.|::.:.|.
Human   326 GQRGRKP-GGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSP-----QDFLSFTDSDL-- 382

  Fly   698 YRAGIRMRDQAAPLFVQVRKELQRDGLLARSQRYHVD---HVEAEVEQE-----LRLLLAAPASE 754
                                   |:...:.||:....   |......||     ...|:..|::.
Human   383 -----------------------RNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTS 424

  Fly   755 GIVQKLLILADKSQVLKN---PTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDED 816
            .:..:.....:....|.|   ||...|:.:...:|...:::..:|....::|..
Human   425 AVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGP----------- 478

  Fly   817 TLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLN 881
               |.|...:.::..:...|        ......|...|......|..|..|........::||:
Human   479 ---GRPKGNKNQENVSHLSV--------SSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLS 532

  Fly   882 NSSSPVGINRRTAILLTRKAQAALKRPSEPLTT------PVKEEQHNSQS-----SNTQSTSGSS 935
            ..|||||    :.|.:..:...|.     |.||      .:....:||..     .|..|.||||
Human   533 VGSSPVG----SEISMQYRHDGAC-----PTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSS 588

  Fly   936 SSVTTAATAASSGAGTLNHVLSSAPPTASS----FALTQNNSSGGGALASGTG--IGGSSSAGTA 994
            :.|:::.....| :|.|..|.:.:|...||    .|.||.|:..|.:|:....  .|..|::..|
Human   589 TPVSSSHLPQQS-SGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMA 652

  Fly   995 AAA-----SLTSTALAMNSK------------LSANLPVKSPK----RPGR--YRRVPEVRHS-- 1034
            |..     :.|...|..||:            ||...||.|.:    :||.  ...:|.|..|
Human   653 ALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIE 717

  Fly  1035 --------------------------------------------SSMSPKKS-----------PN 1044
                                                        .:::.||.           |.
Human   718 QLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPF 782

  Fly  1045 PAVTV------------SQALPMPETLPFERIPDSFRVYRANNQRDVSDSD-DAPSQSSSPCSSC 1096
            |.:|.            :|..|..::|...:.|.....:..:|...|.:.| .:..||:|..|:.
Human   783 PTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSAL 847

  Fly  1097 SDFSMSGSCSDFDSDEASEGD-ADGDPDRDG---GRSRSEERDSTSQEGTTDAMDMQHASLNNVQ 1157
            |....:|      ...|.:|. ..|....:|   |...|..:..||   |..|:......:..:.
Human   848 STPPPAG------QSPAQQGSGVSGVQQVNGVTVGALASGMQPVTS---TIPAVSAVGGIIGALP 903

  Fly  1158 GNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKPMKVGTRGTPTPTTMARAVALSAGRGRGK 1222
            ||  .:||:...|...|       :.:.|::..||          |||.|
Human   904 GN--QLAINGIVGALNG-------VMQTPVTMSQN----------PTPLT--------------- 934

  Fly  1223 RRSNLSESTSSTATPPPLRRAGKLRSAT-PNASPLVNNIKARRNTTAAGSAPLTNNNRS--KHSE 1284
                      .|..||         :|| |..:.|.|        :|:|...|::..|.  .|.:
Human   935 ----------HTTVPP---------NATHPMPATLTN--------SASGLGLLSDQQRQILIHQQ 972

  Fly  1285 --------DSASSERHN-------NHSHGQ--KPALEPLQL 1308
                    ...:.|:|.       .|.|.|  :|.|:.||:
Human   973 QFQQLLNSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQI 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	104/369 (28%)
		Bromo_brd1_like	615..712	CDD:99944	16/108 (15%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	19/87 (22%)
		PWWP_BRPF	1303..1414	CDD:438964	3/6 (50%)
MLLT10	NP_001182555.1	PHD_AF10_AF17	24..71	CDD:277049	20/45 (44%)
		ePHD_AF10	78..206	CDD:277178	61/137 (45%)
		Self-association	80..287		79/288 (27%)
		Required for interaction with histone H3. /evidence=ECO:0000269|PubMed:26439302	106..190		37/90 (41%)
		Interaction with FSTL3. /evidence=ECO:0000269|PubMed:17868029	141..233		28/100 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..260		9/65 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..505		37/273 (14%)
		DNA-binding	311..674		79/425 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..612		10/29 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..708		11/47 (23%)
		Transactivation domain, required for DOT1L-binding	703..784		6/80 (8%)
		CC_AF10	715..778	CDD:411015	3/62 (5%)
		Leucine-zipper	750..778		2/27 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..865		15/70 (21%)