Protein Alignment Br140 and JADE1

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_024309986.1
• Gene: JADE1 / 79960
• HGNCID: 30027
• Length: 857
• Species: Homo sapiens
• Alignment Length: 919
• Identity: 246/919 - (26%)
• Similarity: 382/919 - (41%)
• Gaps: 213/919 - (23%)

  Fly    98 SSASAGGGSAS---GVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAAL 159
            |..|...||.|   ..::|......|...:.:.:.:..|..| ....:.:.|:..|..||.:..
Human    25 SEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTD-LITAMKLHDSYQLNPDEYYVL- 87

  Fly   160 VARGCILNADAPPLEENAPWAR-----VQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSL---- 215
                    ||        ||.:     |||||:          ....|:|:|.....||||
Human    88 --------AD--------PWRQEWEKGVQVPVS----------PGTIPQPVARVVSEEKSLMFIR 126

  Fly   216 ------------EEL---------DGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMD 259
                        .||         |....||:::.|:||||..|||.:.:|:..:...|||.:::
Human   127 PKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLE 191

  Fly   260 RLEKE-----SHFQAAANGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPY 319
            ..|:.     :|......|  .|:|.|:|.||.:|...:.::.|.::|||.||:.|||.|||:..
Human   192 EFEQRCYDNMNHAIETEEG--LGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILK 254

  Fly   320 IPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDS 383
            :|||.||||.|......  .|:|||..|||.|.|..| :|.||.||||||||...:...:|||..
Human   255 VPEGSWLCRTCALGVQP--KCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITK 317

  Fly   384 IETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQ 448
            :..||.:||.|.|.:|.|| .||.|||...:|..|||||||...||  .|.|:. ..||   .|:
Human   318 VSHIPSSRWALVCSLCNEK-FGASIQCSVKNCRTAFHVTCAFDRGL--EMKTIL-AEND---EVK 375

  Fly   449 KFAYCHAHT----PAD-----AKLKMNVPD---------FEDTRHKMKEARKALAKKRSTAPVVL 495
            ..:||..|:    |.:     |..:...|:         |.......:||.:...:|:....:
Human   376 FKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQL-- 438

  Fly   496 IPTIPPDRVQEIATMVTMQR----KKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRN 556
                 .|.......::.:.|    .:|.:|.:..||.|||......||:...:.:.:|  :.:|
Human   439 -----EDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDN--LAKR- 495

  Fly   557 GIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLE---- 617
                  :...|:|:|:.:..|||||||.|.|..:|.:|||:|.:..::.|::..|....||
Human   496 ------EQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERV 554

  Fly   618 ---------AALNKLL---------DALEARD---SMQIFREPVDTSEV-----PDYTD------ 650
                     ::|..:|         ||.:..|   ....||:.:.||.|     |...|
Human   555 SGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSP 619

  Fly   651 ------IVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMI---QNCLAY----NNKDTVFYRAGI 702
                  ::|||...|.....:....:..||:..|:..|:.   :|.:..    ..:|..|:...|
Human   620 GSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLI 684

  Fly   703 R--MRDQAAPLFVQVRKELQRDGLLARSQRYHVDHVEAEVEQELRLLLAAPAS-EGIVQKL---L 761
            :  ::|::   |.|..|.|:...:   ||| |:|:..|.....:.  .:||.: :.||.|.   |
Human   685 KGDLKDKS---FKQSHKPLRSTDV---SQR-HLDNTRAATSPGVG--QSAPGTRKEIVPKCNGSL 740

  Fly   762 ILADKSQ-VLKNPTYRTKKIKQ---IRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSP 822
            |..:.:| .:|.||.....:|.   .|:.....|:...:|...|.| .|::.....    ||..|
Human   741 IKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACH-QHSDYPYLG----LGRVP 800

  Fly   823 SKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPV 887
            :|:|.:.:..|...:.  |:..|.|..||:.::                   |..|.::.||:
Human   801 AKERAKSKLKSDNEND--GYVPDVEMSDSESEA-------------------SEKKCIHTSST-- 842

  Fly   888 GINRRTAIL 896
             |:|||.|:
Human   843 -ISRRTDII 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	152/496 (31%)
		Bromo_brd1_like	615..712	CDD:99944	27/147 (18%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110
		PWWP_BRPF	1303..1414	CDD:438964
JADE1	XP_024309986.1	COG5141	114..>544	CDD:227470	145/456 (32%)
		ePHD_JADE1	270..387	CDD:277174	56/125 (45%)