Protein Alignment Br140 and brpf3

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_031751953.1
• Gene: brpf3 / 779492
• XenbaseID: XB-GENE-6092087
• Length: 992
• Species: Xenopus tropicalis
• Alignment Length: 1443
• Identity: 434/1443 - (30%)
• Similarity: 596/1443 - (41%)
• Gaps: 544/1443 - (37%)

  Fly    54 PLTPVLTPSRKKARSRSGGHHSTPRPH--KDHPTPGGGGAEARNGCSSASAGGGSASGVSARQYA 116
            |.|.:..| |:|.|...||...:|.|:  |..||
 Frog     6 PSTDMRNP-RRKFRHCGGGGKGSPSPYSLKCSPT------------------------------- 38

  Fly   117 NPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNAD------APPLEE 175
              ...::|.:.:..|...::|:..|:.|.|.|.:|.::|..|.....|..|.:      |.|..:
 Frog    39 --RETLTYAQAQRMVEVEMEGRLHRISIYDPLRIVSEDELTAHDIIECNSNKENSELPLASPCRK 101

  Fly   176 NA-----------------------PWARVQVPVARVAEIPDYRVSDAPPRPLAYYRFIEKSLEE 217
            .|                       |..||..|.:...|...|.:.|      ::|.:||:|.:|
 Frog   102 MAFKSKKHELCPKQAQTTSSLQLPQPCFRVIEPFSLEVESEPYSLPD------SFYCYIERSTKE 160

  Fly   218 LDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVDD 282
            :|.|||||:||.|.||||.:||:|:..||:.|..|..|||:|||||||:.|:..:|.|... :|:
 Frog   161 MDQEVEYDLDEVDLAWLEMINEKRKNDGLSLVSADVFELLLDRLEKESYMQSRRSGAPQSA-IDE 224

  Fly   283 DAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAG 347
            ||.||:|||.||.|:|.|||||:|||||||:|||||||||||||||.|||||||||:||||||.|
 Frog   225 DAFCCVCLDDECHNSNAILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSKPVSCVLCPNQG 289

  Fly   348 GAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHR 412
            ||||||..|:|||||||:|||||.|||||||||::.:..||.|||:||||:||:||.||.||||:
 Frog   290 GAFKQTSDGRWAHVVCAIWIPEVCFANTVFLEPVEGVNNIPSARWKLTCYLCKQKGRGAAIQCHK 354

  Fly   413 NSCYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTP----------ADAKL--K 464
            .:||.||||||||:|||:|.::.|:: |.|.::..|:|.|:|..|.|          ...|:  |
 Frog   355 VNCYTAFHVTCAQRAGLFMKVEPVRETGLNGTTFTVRKTAFCELHCPPGTHKKGILRCGGKVDNK 419

  Fly   465 MNVPDFEDTRHKMKEARKALAKK-----------------RSTAPVVLIPTIPPDRVQEIATMVT 512
            .|..:.|..|...|.::|...|:                 |.:|||:.:..||..|:.:|::.|.
 Frog   420 DNGKEDEANREDSKFSKKGAGKRGREKQKIKREQKETVCGRVSAPVMTVMQIPSCRLSKISSGVC 484

  Fly   513 MQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNG--IEGSPDTGELYRQLKYWQ 575
            :|:|..||.|:..||.|||..||||||:|||.|    |...||:.  .|....|..:..:|||||
 Frog   485 LQKKTHFLQRLHNYWLLKRQSRNGVPLIRRLHS----HMQSQRSAELKEQDERTSAVKEELKYWQ 545

  Fly   576 CLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPV 640
            .||.||||||||.||:|||||||...|::.:..:.|||.|....|...||.|:.:||..||.|||
 Frog   546 KLRHDLERARLLTELIRKREKLKREQVKLHQAAMELQLTPFTVFLRTTLDLLQEKDSANIFTEPV 610

  Fly   641 DTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMR 705
            :..|||||.:.:..|||..|||.||:..||.||...|.||:||:.|||.||:::|||::|.:|:.
 Frog   611 NLKEVPDYRNFIVHPMDFSTMRQKLEGHQYTSLHAFEDDFNLMVSNCLRYNSQETVFHQAALRLH 675

  Fly   706 DQAAPLFVQVRKELQRDG------LLARSQRYHVDHVEAEVEQELRLLLAAPASEGIVQ---KLL 761
            ...|.:....|::::..|      |....|....|:.....::..:|||  |.:...:.   :|.
 Frog   676 QLGAAILRHARRQVESTGYDPQTCLHLPEQPRTADYYRVSWDEVDQLLL--PENRAHLSPECQLK 738

  Fly   762 ILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSPSKKR 826
            .|.:|.:|:.  ::||...:..||.:.|...:|.:.|.|.|
 Frog   739 ELLEKLEVVN--SFRTSGARTRRLRLLRKEINLLRQRLAPR------------------------ 777

  Fly   827 TRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINR 891
                            ..|.:|.|
 Frog   778 ----------------SRDPQETD----------------------------------------- 785

  Fly   892 RTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAATAASSGAGTLNHVL 956
                                                                     ||.:|
 Frog   786 ---------------------------------------------------------AGVIN--- 790

  Fly   957 SSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPVKSPKR 1021
                                       |.|..:.:|:.:.:|...:.|.:.:...:.:|:..|
 Frog   791 ---------------------------GFGNHTESGSDSDSSSVLSRLTVLNCCGSLMPLGKP-- 826

  Fly  1022 PGRYRRVPEVRHSSSMSPKKSPNPAVTVSQALPMPETLPFERIPDSFRVYRANNQRDVSDSDDAP 1086
              ...|||.                              ||
 Frog   827 --ALLRVPF------------------------------FE------------------------ 835

  Fly  1087 SQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDGGRSRSEERDSTSQEGTTDAMDMQHA 1151
                         :|:|   |||
 Frog   836 -------------TMNG---DFD------------------------------------------ 842

  Fly  1152 SLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKPMKVGTRGTPTPTTMARAVALSA 1216
              .|.||.
 Frog   843 --YNYQGR--------------------------------------------------------- 848

  Fly  1217 GRGRGKRRSNLSESTSSTATPPPLRRAGKLRSATPNASPLVNNIKARRNTTAAGSAPLTNNNRSK 1281
                                                 |||:
 Frog   849 -------------------------------------SPLM------------------------ 852

  Fly  1282 HSEDSASSERHNNHSHGQKPALEPLQLVWAKCRGYPWYPALILDPKTPK-GFVYNGVPLPAPPTD 1345
             |.|:...             |:|||||||||||||.|||||:|||.|: |.::||||:|.||.:
 Frog   853 -SFDAGVE-------------LQPLQLVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLE 903

  Fly  1346 VLALRK----NCLDEIVFLVLFFDVKRTWQWLPANKLDILGIDKQLDQQKLVESRKPAERKAVKK 1406
            ||.|.:    ....:.:|||||||.||||||||::|:..||.|..||:.|::|.||.:.||:|:.
 Frog   904 VLNLGEQRHIEAEGQQLFLVLFFDNKRTWQWLPSDKVIPLGADDTLDKLKMLEGRKASIRKSVQV 968

  Fly  1407 AYQDALHYQSQVS 1419
            ||..|::::|:||
 Frog   969 AYDRAMNHRSRVS 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516	2/6 (33%)
		COG5141	203..>625	CDD:227470	235/453 (52%)
		Bromo_brd1_like	615..712	CDD:99944	45/96 (47%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	8/82 (10%)
		PWWP_BRPF	1303..1414	CDD:438964	65/115 (57%)
brpf3	XP_031751953.1	EPL1	58..207	CDD:463128	51/154 (33%)
		COG5141	165..610	CDD:227470	236/449 (53%)
		PHD_SF	282..399	CDD:473978	75/116 (65%)
		Bromodomain	585..682	CDD:445827	45/96 (47%)
		PWWP_BRPF3	860..978	CDD:438986	65/117 (56%)