Protein Alignment Br140 and brd1

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001073031.1
• Gene: brd1 / 733743
• XenbaseID: XB-GENE-949377
• Length: 1185
• Species: Xenopus tropicalis
• Alignment Length: 1415
• Identity: 486/1415 - (34%)
• Similarity: 679/1415 - (47%)
• Gaps: 333/1415 - (23%)

  Fly   101 SAGGGSASGVSARQYANPESLVSYNEEEATVTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCI 165
            ||...|.|..|.:.....|:| :|.:.:..|...::|:..|:.|.|.|.:|.:::..|.....|.
 Frog    11 SAPRSSTSPCSIKHSPTRETL-TYAQAQRMVEIEIEGRLHRISIFDPLEIVSEDDLTAQEINECN 74

  Fly   166 L---NADAPP----------------LEENAPWARVQVPVARVAEIPDYRVSD-----APPRPLA 206
            .   |::.||                ..|..|.|......:.:.| |..||.:     ||.|..:
 Frog    75 SNKENSEQPPQVCLRSKRHKASKEKKKSEVLPTAHGHTTTSVLPE-PKVRVIECSPPSAPNRSPS 138

  Fly   207 YYRFIEKSLEELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAA 271
            ||:|.:||.||||.|||||:||||.||||.:||:|:..|.:||..|..|.||||.||||:.:...
 Frog   139 YYKFQDKSPEELDKEVEYDMDEEDYAWLEIINEKRKSEGFSAVSQDIFEFLMDRFEKESYCENQK 203

  Fly   272 NGTPTGVEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSK 336
            .|....: :|:|||||||:||||||:|||||||||||||||:|||||||||||||||.||||.:.
 Frog   204 QGDQQSL-IDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRNI 267

  Fly   337 PVNCVLCPNAGGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKE 401
            |::||||||.|||||:||..:|.|||||||||||.||||||:||||.:..||||||:||||:||:
 Frog   268 PIDCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQ 332

  Fly   402 KGLGACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTPADAKLK- 464
            ||:|||||||:.:||.||||||||:|||||.|:.||: ..:.::..|:|.|||.||||.....:
 Frog   333 KGVGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKEVAGSITTFSVKKTAYCDAHTPPGCVRRP 397

  Fly   465 -------------------MNVPDFEDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATM 510
                               .|:......|.|..:|:|.|.:..:..|.:.:|.|||.||.:|...
 Frog   398 LNIYEEPESKNGICRKSSDKNIRSTSKARRKTTKAKKELNETCNVLPTITVPDIPPQRVNKIINQ 462

  Fly   511 VTMQRKKEFLDRIIAYWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGE---LYRQLK 572
            |::.|||:|::|:.:||.|||..|||:||||||||...:    ||| |:.|.|..|   |.::||
 Frog   463 VSIPRKKQFIERVHSYWMLKRLSRNGIPLLRRLQSSLQS----QRN-IQESEDDEEVQALKKKLK 522

  Fly   573 YWQCLRQDLERARLLCELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFR 637
            |.|.||.||||||||.||:|||||||...|::.:..:.|:|.||...|..||:.|:.:|..:||.
 Frog   523 YLQRLRHDLERARLLIELIRKREKLKREQVKVEQVAMELKLTPLTVLLRSLLEQLQEKDPARIFA 587

  Fly   638 EPVDTSEVPDYTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGI 702
            .||:.:|||||.|.:|.|||..||:.:|::.:|.:|.:.|.||:|:|:||:.||.|||:||||.:
 Frog   588 HPVNLTEVPDYLDHIKHPMDFSTMKKRLEDQRYRNLNEFEEDFNLIIENCMKYNAKDTIFYRAAV 652

  Fly   703 RMRDQAAPLFVQVRKEL----------------------------QRDGLLARSQRYHVDHVEAE 739
            |:||....|..|.|:|.                            ..|.||..:.|.|:     .
 Frog   653 RLRDHGGVLLRQARREANVIGFDEETGMHLPEQPKIEAPPQFSWEDVDKLLNPNNRAHM-----A 712

  Fly   740 VEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHS 804
            :|::|:.||         :||    |.:..:|:...|:|::|.::.||:.:|:.|.:
 Frog   713 LEEQLKELL---------EKL----DLTFAMKSSGSRSKRLKLLKREIANVRQMLSQ-------- 756

  Fly   805 SHANQSQSDDEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSDEDSMGEDTVSKDLLNST 869
            .|....|.  |..:|.          |...|..:..|.::.|:.....|.|......|....||
 Frog   757 QHVQPPQI--ESGIGS----------FEEDGSMLNDGEEEGDKSPPKLEPSDALPLPSNSETNS- 808

  Fly   870 QTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGS 934
            :.|...||: ||...|              |....:...:|..:|.::.|..|..
 Frog   809 EPPTLKPIE-LNPEQS--------------KLYKRVTFDNELHSTTIQNEMINGH---------- 848

  Fly   935 SSSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASL 999
                            |..::|..:         ..|.||......|.|.:...:|.....:.|:
 Frog   849 ----------------TPENLLKDS---------NLNESSDSEVAESSTDVNRRTSILFRKSKSV 888

  Fly  1000 TSTALAMNSKLSANLPVKSPKRPGRYRRVPEVRHSSSMSPKKSPNPAVTVSQALPMPETLPFERI 1064
                              ||::|.:.      ..:...||:......::|  .||..|||...|
 Frog   889 ------------------SPQKPSKN------TETQPTSPQLGTKTFLSV--VLPRLETLLQPR- 926

  Fly  1065 PDSFRVYRANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDGGRS 1129
                                  .:|.|.|                          ||.:.||
 Frog   927 ----------------------KRSRSTC--------------------------GDSEVDG--- 940

  Fly  1130 RSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNKP 1194
                      |.....:|                     :|.|.|....:.|.|......|:.:|
 Frog   941 ----------ESPVKRLD---------------------TGLSNGYGEGEKEKEFNITPGRKLEP 974

  Fly  1195 MKVGTRGTPTPTTMARAVALSAGRGRGKRRSNLSESTSSTATPP-PLRRAGKLRSATPNASPLVN 1258
                                   |.|....|::|.:.|....|. .|.:.||.:.|.
 Frog   975 -----------------------RRRCASESSISSNNSILCNPSFGLPKCGKGKPAL-------- 1008

  Fly  1259 NIKARRNTTAAGS---APLTNNNRSKHSEDSASSERHNNHSHGQKPA-LEPLQLVWAKCRGYPWY 1319
               .||:|....|   :.:.|.|.::.:..:|...:.|........| ||||::|||||.|||.|
 Frog  1009 ---IRRHTIEDRSELISCIENGNYARAARIAAEVGQTNMWVAASTSAFLEPLKVVWAKCSGYPSY 1070

  Fly  1320 PALILDPKTPK-GFVYNGVPLPAPPTDVLAL---RKNCLDEIVFLVLFFDVKRTWQWLPANKLDI 1380
            ||||:|||.|: |..:|||.:|.||.|||..   .:...:|.:|||||||.||:|||||.:|:..
 Frog  1071 PALIIDPKMPRVGCHHNGVAIPVPPMDVLKTGDQMQTRAEEKLFLVLFFDNKRSWQWLPKSKMVP 1135

  Fly  1381 LGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQV--------SDLE 1422
            ||:|:.:|:.|::|.|..:.||||:.||..||::.|:|        ||::
 Frog  1136 LGVDETIDKLKMMEGRNSSIRKAVRVAYDRALNHLSRVQGESVSDFSDID 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	246/445 (55%)
		Bromo_brd1_like	615..712	CDD:99944	45/96 (47%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	9/82 (11%)
		PWWP_BRPF	1303..1414	CDD:438964	62/114 (54%)
brd1	NP_001073031.1	EPL1	47..196	CDD:463128	55/149 (37%)
		COG5141	139..>571	CDD:227470	243/437 (56%)
		Bromo_brd1_like	565..662	CDD:99944	45/96 (47%)
		PWWP_BRPF2	1054..1173	CDD:438985	63/118 (53%)